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Promoter directionality is controlled by U1 snRNP and polyadenylation signals in mouse embryonic stem cells
(Massachusetts Institute of Technology, 2013)
RNA polymerase II (RNAPII) transcription is a tightly regulated process controlling cell type and state. Advancements in our understanding of how transcription is regulated will provide insight into the mechanisms controlling ...
Dual functions of the retinal determination gene network member EYES ABSENT as a transcription factor and protein phosphatase
(Massachusetts Institute of Technology, 2004)
Regulation of microtubule attachment at the kinetochore and cell cortex
(Massachusetts Institute of Technology, 2016)
During mitosis, the cell divides in two, evenly distributing the genetic material and splitting the rest of cellular contents between the resulting daughter cells. This process is essential, rapid, and complex, requiring ...
Spatial and temporal coordination of genome segregation with activation of the Mitotic Exit Network
(Massachusetts Institute of Technology, 2012)
In budding yeast, an essential Hippo-like signal transduction cascade known as the Mitotic Exit Network (MEN) governs the final cell cycle transition, the mitosis to G1 transition. To ensure the accurate execution of ...
Gut-associated microbial symbionts of the marsh fiddler crab, Uca pugnax
(Massachusetts Institute of Technology, 2004)
(cont.) bacterial phylotypes. An exception was the U. pugnax hindgut phylotype most closely related to a phylotype identified from hindguts of the detritivorous shrimp Neotrypaea califomiensis. This finding suggests that ...
Phenotypic heterogeneity and evolutionary games in microbial populations
(Massachusetts Institute of Technology, 2015)
One of the most interesting discoveries of the last decade is the surprising degree of phenotypic variability between individual cells in clonal microbial populations, even in identical environments. While some variation ...
Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
(Massachusetts Institute of Technology, 2016)
Chemoresistance remains a major barrier to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor ...
Adhesion-GPCRs in cancer progression and metastasis
(Massachusetts Institute of Technology, 2016)
Adhesion-GPCRs, a novel family of G protein-coupled receptors (GPCRs), are characterized by an extended extracellular region linked to a seven-pass transmembrane moiety via GPCR proteolytic site (GPS)-containing stalk ...
Population dynamics and diversity of Synechococcus on the New England shelf
(Massachusetts Institute of Technology, 2014)
Synechococcus is a ubiquitous marine primary producer. Our understanding of the factors that determine its abundance has been limited by available observational tools, which have not been able to resolve population dynamics ...
Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
(Massachusetts Institute of Technology, 2013)
The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...