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The role of XBP1s in the unfolded protein response and N-linked glycosylation
(Massachusetts Institute of Technology, 2020)
The secretory pathway processes approximately one-third of the cellular proteome, modifying proteins with diverse chemical structures such as carbohydrates. These modifications can help guide protein folding and expand the ...
Palladium- and nickel-catalyzed C-N cross-coupling reactions featuring soluble organic bases
(Massachusetts Institute of Technology, 2020)
Chapter 1: Breaking the Base Barrier: An Electron-Deficient Palladium Catalyst Enables the Use of a Common Soluble Base in C-N Coupling Due to the low intrinsic acidity of amines, palladium-catalyzed C-N cross-coupling ...
Re-targeting of anthrax toxin binding for immunomodulation and targeted cancer therapy
(Massachusetts Institute of Technology, 2020)
The intracellular delivery of cytotoxic proteins is a longstanding goal in drug development. This is challenging due to biological membranes, which prevent facile entry of macromolecules into the cellular cytosol. Anthrax, ...
Addressing delivery and synthesis challenges for peptide-based cancer vaccines
(Massachusetts Institute of Technology, 2020)
Therapeutic peptide vaccines have the potential to elicit and direct an anti-cancer T cell response, but their clinical efficacy has been limited in part by poor delivery to the lymphatic system, inefficient cell uptake, ...
Squaric ester applications as novel lysine electrophiles in molecular probe design
(Massachusetts Institute of Technology, 2020)
Small molecule probes for biology have been instrumental in uncovering enzyme mechanisms and developing therapeutics. Covalent probes are valuable because they can irreversibly tag proteins of interest for analysis. Selective ...
New strategies for in vivo continuous directed evolution
(Massachusetts Institute of Technology, 2020)
Continuous in vivo directed evolution facilitates the exploration of large biomolecule libraries at unprecedented speeds. By inserting a biomolecule of interest into a constantly mutating virus whose replicative capacity ...
Mechanical properties of complex solids and exotic thermal transport dynamics investigated with optical and extreme-ultraviolet transient grating techniques
(Massachusetts Institute of Technology, 2020)
In this thesis we investigate the acoustic/mechanical properties and thermal transport phenomena in a range of solids using optical and extreme-ultraviolet transient grating (TG) techniques. A single-crystal (110)-oriented ...
New fundamental transformations of heterocyclic compounds enabled by copper catalysis
(Massachusetts Institute of Technology, 2020)
Chapter One. Introduction to Catalytic C-C⁻Bond⁻Forming Reactions of Alkylcopper(I) Nucleophiles This chapter provides a brief historical perspective on the development of Cucatalyzed C-C⁻bond-forming reactions and an ...
From benchtop to bedside and beyond : the development and application of low- and high-throughput, single-cell RNA-Seq platforms for precision medicine pipelines
(Massachusetts Institute of Technology, 2020)
The development and application of single-cell technologies have revolutionized how we study health and disease. By deconstructing complex biological systems, like human tissues, into the fundamental building blocks of ...
Laser spectroscopy of acetylene
(Massachusetts Institute of Technology, 2020)
The purpose of this thesis is to explore recent advances in the spectroscopy of acetylene. Acetylene is among the most-studied molecules, and an astoundingly large volume of work has been done on it. Highly excited S1 ...