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Distant chaperones and N-glycan signals : new mechanisms of secretory pathway proteostasis
(Massachusetts Institute of Technology, 2018)
Approximately one-third of all cellular proteins traverse the secretory pathway. After translation and folding in the endoplasmic reticulum (ER), proteins are transported through the Golgi to their final locations inside ...
Directed evolution of TurboID for efficient proximity labeling in living cells and organisms
(Massachusetts Institute of Technology, 2018)
Protein interaction networks and protein compartmentalization underlie all signaling and regulatory processes in cells. Traditional approaches to proteomics employ mass spectrometry (MS) coupled to biochemical fractionation ...
Carbon dioxide utilization : from fundamental reactivity to catalysis using transition metals supported by macrocyclic diphosphines
(Massachusetts Institute of Technology, 2017)
Molybdate, a molecular metal oxide, readily binds CO₂ at room temperature to produce a robust monocarbonate complex, [MoO₃(k²-CO₃)]²-. In the presence of excess CO₂, a pseudo-octahedral dioxo dicarbonate complex, ...
Manipulating Conjugation in electronic polymers and graphitic materials: chemosensors, precursor routes, and self-assembly
(Massachusetts Institute of Technology, 2015)
In Chapter 1, we synthesize dithienobenzotropone-based conjugated alternating copolymers by direct arylation polycondensation. Post-polymerization hydride reduction furnishes cross-conjugated copolymeric hydrogels that ...
New reactions and reagents for phosphorus-carbon bond-formation
(Massachusetts Institute of Technology, 2020)
Chapter 1 takes the format of an "Outlook", and sets forth the case for developing sustainable methods in the synthesis of phosphorus-containing compounds. Methods used by nature for phosphorus-carbon bond-formation, or ...
Assessing and improving the regulatory compliance and end-of-life environmental impacts of lead-based thin-film photovoltaics
(Massachusetts Institute of Technology, 2020)
Emerging thin film photovoltaics (PVs) with photoactive layers based on quantum dots (QDs) and perovskites are a promising source of low-carbon renewable energy. Their solution-processability and compatibility with flexible ...
Methane mono-oxidation electrocatalysis by palladium and platinum salts
(Massachusetts Institute of Technology, 2020)
Selective oxidation of methane to methanol would enable better utilization of natural gas resources. Many homogeneous metal ions activate methane under mild conditions, but turning this reactivity into catalysis requires ...
Through-bond and through-space charge transport in metal-organic frameworks
(Massachusetts Institute of Technology, 2020)
Electrically conductive metal-organic frameworks (MOFs) combine intrinsic porosity with efficient charge transport, opening up possibilities as active materials for applications ranging from electrocatalysis to chemiresistive ...
Design and application of polymer metal-organic cage gels
(Massachusetts Institute of Technology, 2020)
Chapter 1. A unifying overview of the fundamentals of polymer network synthesis, structure, and properties is provided, tying together recent trends in the field that are not always associated with classical polymer networks, ...
Single-cell methods for profiling tumor & microenvironment responses to therapeutic challenges
(Massachusetts Institute of Technology, 2020)
Heterogeneity among cells affects function and dysfunction across many complex biological systems. This heterogeneity is particularly important in cancer biology, where variation in the cells composing tumors and their ...