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Identification of new functions for BRCT domains
(Massachusetts Institute of Technology, 2008)
Our lab identified the tandem BRCT domains of PTIP function as a DNA damage responsive phospho binding domain that recognizes proteins phosphorylated by ATM and ATR after DNA damage. The PTIP tandem BRCT domains are ...
Investigating immune surveillance, tolerance, and therapy in cancer
(Massachusetts Institute of Technology, 2009)
Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...
Insights into the role and mechanism of the AAA+ adaptor Clps
(Massachusetts Institute of Technology, 2009)
Protein degradation is a vital process in cells for quality control and participation in regulatory pathways. Intracellular ATP-dependent proteases are responsible for regulated degradation and are highly controlled in ...
Identification of a novel metastasis enhancer, CDCP1, and analysis of its functions during melanoma metastasis
(Massachusetts Institute of Technology, 2009)
Nearly 90% of cancer mortality from solid tumors is due to metastasis of malignant cells to the distant vital organs. It is now well established that a plethora of stromal cells are present within the tumor, and contribute ...
Involvement of cytochrome P450 1A in the toxicity of aryl hydrocarbon receptor agonists : alteration of arachidonic and acid metabolism and production of reactive oxygen species
(Massachusetts Institute of Technology, 1998)
Two cytochrome P4501A-dependent mechanisms of aryl hydrocarbon receptor (AhR) agonist toxicity were examined in the marine teleost scup (Stenotomus chrysops), alteration of arachidonic acid (AA) metabolism and production ...
Functional connectivity of coral reef fishes in a tropical seascape assessed by compound-specific stable isotope analyses
(Massachusetts Institute of Technology, 2011)
The ecological integrity of tropical habitats, including mangroves, seagrass beds and coral reefs, is coming under increasing pressure from human activities. Many coral reef fish species are thought to use mangroves and ...
The Importance of RNA Pairing Stability and Target Concentration for Regulation by MicroRNAs
(Massachusetts Institute of Technology, 2012)
Regulation of gene expression in eukaryotes is highly precise and complex. Changes in expression can define the fate of each cell, convert healthy tissues to diseased ones, and even lead to speciation. Regulation occurs ...
In vivo pool-based shRNA screens to identify modulators of disease progression in hematopoietic malignancies
(Massachusetts Institute of Technology, 2012)
shRNA screens have been very effective in identifying novel cancer genes in mammalian cells, but they have primarily been limited to in vitro applications in tumor cell lines. Whereas in vivo retroviral mutagenesis screens ...
The cell-secreted microenvironment : shaping embryonic stem cell self-renewal and differentiation
(Massachusetts Institute of Technology, 2012)
The objective of this work is to obtain an in depth understanding of how embryonic stem cell-secreted signals contribute to their identity. We analyze the contribution of broad and specific signals present in the cell-secreted ...
Protein quality control in the mammalian endoplasmic reticulum
(Massachusetts Institute of Technology, 2011)
Quality control is an important part of protein biogenesis. Aberrant proteins must be destroyed before they aggregate and cause deleterious effects. Failure to do so can result in cell death or malfunction and, ultimately, ...