Now showing items 13-15 of 23305

    • Structural characterization and antibiotic development for the Neisseria gonorrhoeae class Ia ribonucleotide reductase 

      Dorfeuille, Andrew Leonard Jacques (Massachusetts Institute of Technology, 2025-09)
      Ribonucleotide reductases (RNRs) are essential enzymes that catalyze the reduction of ribonucleotides to deoxyribonucleotides, a critical step in DNA biosynthesis and repair. Class Ia RNRs, found in eukaryotes and many ...
    • Generalizable Reinforcement Learning for Network Control 

      Wigmore, Jerrod (Massachusetts Institute of Technology, 2025-09)
      This thesis confronts the critical generalization gap of Deep Reinforcement Learning (DRL) that hinders its effective application to queueing network control, where policies often fail to perform robustly in unseen topologies ...
    • Local Competition, Number and Definitness 

      Doron, Omri (Massachusetts Institute of Technology, 2025-09)
      In this dissertation, I explore the consequences of local competition inside the DP. I argue that various phenomena, including multiplicity inferences, homogeneity and definiteness, are best explained as locally-triggered ...