This is an archived course. A more recent version may be available at ocw.mit.edu.

Assignments

Assigned readings in Branden and Tooze are from the course textbook:

Buy at Amazon Branden, Carl, and John Tooze. Introduction to Protein Structure. 2nd ed. New York, NY: Garland Science, 1999. ISBN: 9780815323051.

Solutions are available for a selected assignments.

ASSIGNMENTS SOLUTIONS READINGS ASSIGNMENTS DUE

Assignment 1 (PDF)

  

Branden and Tooze. Chapter 1 and chapter 2, pp. 13-17.

Pauling, Linus, Robert B. Corey, and H. R. Branson. "The Structure of Proteins: Two Hydrogen Bonded Helical Configurations of the Polypeptide Chain." Proc Nat Acad Sci 37 (1951): 205-210.

Perutz, Max F. "I Wish I'd Made you Angry Earlier." In I Wish I'd Made you Angrier Earlier: Essays on Science, Scientists & Humanity. Cold Springs Harbor Lab Press, 1998, pp. 173-174.

Graduate students only

Pauling, Linus, Robert B. Corey, and H. R. Branson. "The Structure of Proteins: Two Hydrogen Bonded Helical Configurations of the Polypeptide Chain." Proc Nat Acad Sci, USA 37 (1951): 205-210.

 Ses #4

Assignment 2 (PDF)

  

Anfinsen, C. B., E. Haber, M. Sela, and F. H. White, Jr. "The Kinetics of Formation of Native Ribonuclease During Oxidation of the Reduced Polypeptide Chain." PNAS 47 (1961): 1309-1314.

Branden and Tooze. Chapters 2 and 3.

Gusker, J. P. "Crystallizing the Life of Dorothy Hodgkin." Chem Eng News 78 (2000): 28-30.

Not required

Pauling, Linus. "Modern Structural Chemistry." Nobel Prize Lecture. Stockholm, Sweden, 1954.

———. "Science and Peace." Nobel Prize Lecture. Stocholm, Sweden, 1962.

  

Assignment 3 (PDF)

   Branden and Tooze. Chapter 4 and chapter 5, pp. 67-80. Ses #8

Assignment 4 (PDF)

   Branden and Tooze. Chapter 15. Ses #10

Assignment 5 (PDF)

Assignment 5 key (PDF)

Marquesee, Susan, and Robert L. Baldwin. "A-Helix Formation by Short Peptides in Water." Protein Folding: Deciphering the Second Half of the Genetic Code. Edited by Lila M. Gierasch, and Jonathan King. Washington, DC: AAAS, 1990.

Richardson, Jane S., and David C. Richardson. "Amino Acid Preferences for specific Locations at the Ends of a Helices." Science 240 (1988): 1648-1652.

Presta, L. G., and G. D. Rose. "Helix Signals in Proteins." Science 240 (1988): 1632-1640.

Graduate students only

Harper, E. T. and G. D. Rose. "Helix Stop Signals in Proteins and Peptides: The Capping Box." Biochemistry 32 (1993): 7605-7609.

 Ses #13

Assignment 6 (PDF)

Assignment 6 key (PDF)

Branden and Tooze. pp. 286-297.

O'Shea, E., R. Rutkowski, and P. S. Kim. "Evidence that the Leucine Zipper is a Coiled Coil." Science 243 (1989): 538-542.

 Ses #14

Assignment 7 (PDF)

  

Branden and Tooze. Chapter 14.

Kuivaniemi, H., G. Tromp, and D. J. Prockop. "Mutations in Collagen Genes: Causes of Rare and Some Common Diseases in Humans." FASEB Journal 5 (1991): 2025-2060.

 Ses #16

Graded problem set (PDF)

Problem set key (PDF)

   Ses #20