Course Meeting Times
Lectures: 3 sessions / week, 1 hour / session
Recitations: 1 session / week, 1 hour / session
This course is divided into four subject area modules as described in the following table.
Size and Components of Cells and Implications with respect to Regulation
Fatty Acid Synthases (FAS), Polyketide Synthases (PKS), and Non-ribosomal Polypeptide Synthases (NRPS)
Translation: Loading, Initiation, Elongation, and Termination - A Machine in Action; Introduction to G-proteins: Switches or Motors
Crypts and Chambers: Macromolecular Machines involved in Protein Folding and Degradation
|Problem Sets||Will not be graded, but will be dicussed in Recitations|
|Final Exam||200 (Comprehensive)|
Recitations (Techniques and Discussion Sessions)
For one hour each week, Professor Ting will provide an in-depth view of technologies briefly outlined in class and used in the assigned journal papers. These classes will also be used to go over problem sets and to discuss lectures.
Assigned reading will include sections from your textbook to refresh your memory or to give you a good overview of a specific topic. It will also include a review article on each module to bring you up to date about recent advances in a specific area and an original paper that will highlight the use of a technique to solve a problem covered within the module. Additional background reading will be placed on reserve. Additional references will be given for those so inclined to read about one specific topic in more detail.
In class, we will demonstrate three-dimensional structures using Rasmol, a molecular visualization program. We will provide the pdb files along with Rasmol scripts for the structures discussed per module, so that students can view them at their leisure.