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Process Analytical Technology in biopharmaceutical manufacturing
(Massachusetts Institute of Technology, 2013)
Process Analytical Technology (PAT) became a well-defined concept within the pharmaceutical industry as a result of a major initiative by the FDA called "Pharmaceutical cGMPs for the 21st Century: A Risk-Based Approach." ...
Application of manufacturing tools in the DNA sequencing process
(Massachusetts Institute of Technology, 1999)
Product management framework for the development of automation solutions for biologics drug substance manufacturing
(Massachusetts Institute of Technology, 2020)
This thesis presents a product management framework for the development of innovative manufacturing automation solutions, and the application of this framework to the development of automation for a continuous biomanufacturing ...
Development of a methodology for the rapid implementation of a sustainable lean manufacturing system
(Massachusetts Institute of Technology, 2000)
Increasing awareness of the competitive edge that the Toyota Production System (TPS) has afforded to the Toyota Motor Company has led many U.S. companies to implement a lean production system of th~ir own. However, most ...
Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center
(Massachusetts Institute of Technology, 2005)
The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...
Using design of experiments to improve a batch chemical process
(Massachusetts Institute of Technology, 2010)
Novartis Vaccines and Diagnostics has made a strong commitment to manufacturing seasonal influenza vaccines through their cell culture technology called Optaflu®. The goal of this project is to improve overall process yield ...
The business case for continuous manufacturing of pharmaceuticals
(Massachusetts Institute of Technology, 2010)
Manufacturing in the pharmaceutical industry is presently characterized as a batch production system, which has existed in its current form for decades. This structure is the result of historical regulatory policy as well ...
Strategic development of a manufacturing execution system (MES) for cold chain management using information product mapping
(Massachusetts Institute of Technology, 2011)
The Vaccines & Diagnostics (V&D) division of Novartis recently developed a global automation strategy that highlights the need to implement a manufacturing execution system (MES). Benefits of an MES (electronic production ...
Integrating cost consequences into a high quality manufacturing environment
(Massachusetts Institute of Technology, 2003)
Intel Corporation, the world leader in manufacturing microprocessors, has beer successful in achieving high margins because of its ability to successfully deliver high volume and reliable microprocessors at high demand. ...
Transfer of an evolving technology
(Massachusetts Institute of Technology, 1995)
This thesis follows the transfer of a thin film from development to manufacturing. Problems of differences in equipment and differences in manufacturing methods were overcome to complete the transfer. The film was characterized ...