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Lean principles in an aircraft assembly process
(Massachusetts Institute of Technology, 2018)
A universal imperative of most manufacturing firms is to lower cost, increase production rate, and deliver exceptional quality for every product. The manufacturing firm that springs to mind as the standard bearer for all ...
Quantifying the business case for aerospace assembly automation
(Massachusetts Institute of Technology, 2017)
As aerospace Original Equipment Manufacturer's (OEM's) order backlogs soar to between six to ten years and growing, the community sees automation as vital to increasing throughput. Yet the community seems divided on the ...
Crystal ball planning for analytics implementation in Singapore
(Massachusetts Institute of Technology, 2014)
Amgen is building a new drug substance manufacturing site in Singapore (ASM). This project identified and mitigated the risks associated with implementing analytical technologies to facilitate the design and implementation ...
Implementation of a manufacturing technology roadmapping initiative
(Massachusetts Institute of Technology, 2012)
Strategic technology planning is a core competency of companies using technological capabilities for competitive advantage. It is also a competency with which many large companies struggle due to the cross-functional ...
Reducing total fulfillment costs through distribution network design optimization
(Massachusetts Institute of Technology, 2013)
Compared to legacy retailers, online retailers have the potential to better accommodate buyer needs by offering more service time and inventory options. One fundamental operational challenge faced by most online businesses ...
Continuous improvement at a multinational company : dealing with uncertainty in the global supply chain and analyzing implementation dynamics
(Massachusetts Institute of Technology, 2013)
This thesis explores the problem of global supply chain flexibility in the context of a multinational commonly that we refer to as Company X. Company X faces competitive markets, increasingly demanding customers, and ...
A systems approach to reducing utility billing errors
(Massachusetts Institute of Technology, 2013)
Many methods for analyzing the possibility of errors are practiced by organizations who are concerned about safety and error prevention. However, in situations where the error occurrence is random and difficult to track, ...
Simulation and optimization of outbound operations in an e-grocer's warehouse
(Massachusetts Institute of Technology, 2018)
A second wave of online grocery retailers ("e-grocers") emerged in late 2000's after dot.com companies, such as Webvan, Streamline and Homegrocer, failed to break into the grocery market despite investing heavily on automated ...
Enhancing the design and procurement of single-use assemblies in biomanufacturing by implementing modular specifications
(Massachusetts Institute of Technology, 2018)
Usage of single-use systems (SUS) in biomanufacturing has expanded rapidly in recent years. Amgen uses SUS at several commercial manufacturing sites, in addition to pilot plants and clinical production. Each single-use ...
Evaluation of predictive computational modelling in biologic formulation development
(Massachusetts Institute of Technology, 2017)
Computational modelling has completely redefined the experimentation process in many industries, allowing large sets of design concepts to be tested quickly and cheaply very early in the innovation process. Harnessing the ...