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Distribution of mutant cells in human skin : exploration of the fetal-juvenile mutability hypothesis
(Massachusetts Institute of Technology, 2009)
The multiple "hits" carcinogenesis models are extensions of the cancer incidence theory developed by researchers from Nordling (1953), Armitage-Doll (1954 and 1957), Knudson (1971), Moolgavkar and Verzon (1979), to Moolgavkar ...
Transcriptional divergence and conservation of human and mouse erythropoiesis
(Massachusetts Institute of Technology, 2014)
Mouse models have been used extensively for decades and have been instrumental in improving our understanding of mammalian erythropoiesis. Nonetheless, there are several examples of variation between human and mouse ...
Developing a robust harvest for high cell density CHO cell culture
(Massachusetts Institute of Technology, 2020)
A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage
(Massachusetts Institute of Technology, 2011)
Objectives: 1) To perform a quantitative comparison of proteins released to media on combination with cytokine (IL-1[beta[ or TNF-[alpha]) and Injury as compared to either treatment alone, and to thus identify proteins ...
EMG control of prosthetic ankle plantar flexion
(Massachusetts Institute of Technology, 2011)
Similar to biological human ankle, today's commercially available powered ankle-foot prostheses can vary impedance and deliver net positive ankle work. These commercially available prostheses are intrinsically controlled. ...
Process Improvement in Biotech : Dealing with High Complexity Processes
(Massachusetts Institute of Technology, 2009)
Across numerous conventional manufacturing sites, process improvement initiatives have been shown to increase production capabilities while decreasing costs - all without a required system- wide overhaul of the manufacturing ...
Behavioral and genetic characteristics of intestinal cell lineages in health and disease
(Massachusetts Institute of Technology, 2013)
The intestinal crypt is a highly dynamic system, as the entire epithelium is constantly turned over and renewed by the proliferative stem cells located at the bottom of the crypt. While this system is crucial for nutrient ...
Environmental remediation and biofuel production through nanoparticle stimulation of yeast
(Massachusetts Institute of Technology, 2019)
Artificially photosynthetic systems aim to store solar energy and chemically reduce carbon dioxide. These systems have been developed in order to use light to drive processes for carbon fixation into biomass and/or liquid ...
Development and application of tools for glycan characterization
(Massachusetts Institute of Technology, 2009)
Glycans are essential components of all living things because they function as key elements of cellular membranes and extracellular spaces by mediating cell-cell communication, transduction pathways, and cellular development, ...
The roles of diet and SirT3 levels in mediating signaling network changes in insulin resistance
(Massachusetts Institute of Technology, 2013)
The goal of my research is to understand the mechanism by which high fat diets mediate insulin sensitivity and the role SirT3 plays in high fat diet-induced insulin resistance. Insulin resistance is defined as the inability ...