An Expectation Maximization Approach for Integrated Registration, Segmentation, and Intensity Correction

Abstract

This paper presents a statistical framework which combines the registration of an atlas with the segmentation of MR images. We use an Expectation Maximization-based algorithm to find a solution within the model, which simultaneously estimates image inhomogeneities, anatomical labelmap, and a mapping from the atlas to the image space. An example of the approach is given for a brain structure-dependent affine mapping approach. The algorithm produces high quality segmentations for brain tissues as well as their substructures. We demonstrate the approach on a set of 30 brain MR images. In addition, we show that the approach performs better than similar methods which separate the registration from the segmentation problem.