Browsing MIT Open Access Articles by Author "O'Brien, James P."

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    • Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer 

      Papagiannakopoulos, Thales; Olenchock, Benjamin A.; Heyman, Julia E.; Jha, Abhishek K.; Pierce, Kerry A.; e.a. (Elsevier, 2016-02)
      Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied. We infused mice with lung ...