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Now showing items 11-20 of 32
The conclusion of a biologic's lifecycle : manufacturing sourcing strategies on the eve of follow-on biologics
(Massachusetts Institute of Technology, 2008)
The Amgen Rhode Island facility is dedicated to the production of the biological bulk drug substance (BDS) for Enbrel® (etanercept), which blocks the action of one's immune system, helping to treat immune diseases, such ...
Application of lean and continuous improvement methodologies at a biopharmaceutical manufacturing site
(Massachusetts Institute of Technology, 2009)
Heightened competitive pressures, changes in the regulatory atmosphere, and dropping research and development productivity have been plaguing the pharmaceutical and biotechnology industries. Amgen has felt the effects of ...
Development of a methodology for the rapid implementation of a sustainable lean manufacturing system
(Massachusetts Institute of Technology, 2000)
Increasing awareness of the competitive edge that the Toyota Production System (TPS) has afforded to the Toyota Motor Company has led many U.S. companies to implement a lean production system of th~ir own. However, most ...
Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center
(Massachusetts Institute of Technology, 2005)
The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...
Integrating cost consequences into a high quality manufacturing environment
(Massachusetts Institute of Technology, 2003)
Intel Corporation, the world leader in manufacturing microprocessors, has beer successful in achieving high margins because of its ability to successfully deliver high volume and reliable microprocessors at high demand. ...
A "go to market" strategy : enabling P&G profitable share growth through streamlined logistics
(Massachusetts Institute of Technology, 2002)
The cosmetics industry is an intensely competitive, fashion-driven industry. As such, new product launch processes are viewed to be a competitive advantage in promoting continued brand awareness in the market place. However, ...
The use of strategic inventory and packaging postponement to address daily demand variability and seasonal demand patterns in a demand flow environment
(Massachusetts Institute of Technology, 2000)
This LFM thesis describes how Eastman Kodak Company (Kodak) used a strategic buffer of in process inventory and delayed final packaging of end-items to address two issues that surfaced after a recent implementation of a ...
Evaluation wastewater treatment technologies at Ford Powertrain
(Massachusetts Institute of Technology, 2000)
In preparation for an upcoming EPA proposal regarding Free Oil & Grease (FOG) and metal ion content in wastewater effluent, a study was performed for Ford Motor Company that assesses various seconctary wastewater treatment ...
Implementation of new technology in a regulated environment
(Massachusetts Institute of Technology, 2004)
This thesis investigates potential improvements to the manufacturing process through the implementation of process analytical technologies (PAT) in the heavily regulated pharmaceutical industry. The thesis focuses on the ...
A comparative analysis of diagnostic tools and techniques for manufacturing business support
(Massachusetts Institute of Technology, 2004)
The overriding objective of diagnostic assessment is change. Assessment processes are a mechanism to identify areas that merit change. In order to maximize the possibility that a company will adopt recommended changes ...