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A systems approach to procurement of automated technology
(Massachusetts Institute of Technology, 2015)
Company A's Product Group B (PGB) is developing an automated system to complete final assembly of the Component, a structural member of the product that includes technology supporting two features of the product's competitive ...
Identification of leading indicators for producibility risk in early-stage aerospace product development
(Massachusetts Institute of Technology, 2015)
Producibility is an emergent property of product development and manufacturing systems that encapsulates quality, product compliance, cost, and schedule. Detailed product definition and process variation have traditionally ...
Value creation through intellectual property acquisition
(Massachusetts Institute of Technology, 2015)
After Sanofi acquired intellectual property (IP) from bankrupt Pelikan Technologies it desired to leverage the IP to identify a product concept to enhance the company's portfolio. To facilitate the project, a structured ...
Understanding supply chain trade-offs through models and scenario planning with a focus on postponement
(Massachusetts Institute of Technology, 2015)
The two objectives of this project were to develop an understanding of the challenges and opportunities of the supply chain of a family of currently marketed products manufactured overseas and distributed/sold worldwide ...
Uncovering opportunities for cost containment and operational improvements via shared practices between device manufacturer and hospital
(Massachusetts Institute of Technology, 2015)
Background: Medical device manufacturers (suppliers) and hospitals (providers) face financial and operational stressors exacerbated by recent healthcare reform. Providers now face the prospect of decreased reimbursements ...
Optimized distribution supply chain for improved customer service
(Massachusetts Institute of Technology, 2015)
In an attempt to attract consumers, companies are offering an increasingly wide range of product varieties to cater to each consumers individual needs and desires. This behavior leads to fragmentation of demand that increases ...
New approach to drug product process design : leveraging first principles modeling and cross-product process monitoring to improve process design robustness
(Massachusetts Institute of Technology, 2015)
Abstract The vision of the Operations Technology Group at Amgen is to enable a robust pipeline through focused and efficient operations research studies. Process design is traditionally developed by performing experiments, ...
Impact of distributed generation of solar photovoltaic (PV) generation on the Massachusetts transmission system
(Massachusetts Institute of Technology, 2015)
After reaching 250 megawatt direct current (MW dc) of solar photovoltaic (PV) generation installed in Massachusetts (MA) in 2013, four years ahead of schedule, Governor Deval Patrick in May of 2013 announced an increase ...
Evaluation of postponement in the Drug Product supply chain
(Massachusetts Institute of Technology, 2015)
This thesis evaluates the use of postponement in the Drug Product (DP) supply chain at Amgen, which is characterized by highly variable production lead times. The motivation for the use of postponement in the DP supply ...
Diagnosing intensive care units and hyperplane cutting for design of optimal production systems
(Massachusetts Institute of Technology, 2015)
This thesis provides a new framework for understanding how conditions, people, and environments of the Intensive Care Unit (ICU) effect the likelihood the preventable harm will happen to a patient in the ICU. Two years of ...