dc.contributor.author | Kuo, Szu-Yu | |
dc.contributor.author | Castoreno, Adam B. | |
dc.contributor.author | Aldrich, Leslie N. | |
dc.contributor.author | Lassen, Kara G. | |
dc.contributor.author | Goel, Gautam | |
dc.contributor.author | Dancik, Vlado | |
dc.contributor.author | Kuballa, Petric | |
dc.contributor.author | Latorre, Isabel | |
dc.contributor.author | Conway, Kara L. | |
dc.contributor.author | Sarkar, Sovan | |
dc.contributor.author | Maetzel, Dorothea | |
dc.contributor.author | Jaenisch, Rudolf | |
dc.contributor.author | Clemons, Paul A. | |
dc.contributor.author | Schreiber, Stuart L. | |
dc.contributor.author | Shamji, Alykhan F. | |
dc.contributor.author | Xavier, Ramnik J. | |
dc.date.accessioned | 2016-02-05T12:57:03Z | |
dc.date.available | 2016-02-05T12:57:03Z | |
dc.date.issued | 2015-08 | |
dc.date.submitted | 2015-05 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/101110 | |
dc.description.abstract | Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. These findings have motivated the use of small-molecule probes to study how modulation of autophagy affects disease-associated phenotypes. Here, we describe the discovery of the small-molecule probe BRD5631 that is derived from diversity-oriented synthesis and enhances autophagy through an mTOR-independent pathway. We demonstrate that BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease. | en_US |
dc.description.sponsorship | Skoltech Center | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01-NS088538) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant MH104610) | en_US |
dc.language.iso | en_US | |
dc.publisher | National Academy of Sciences (U.S.) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1512289112 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | National Academy of Sciences (U.S.) | en_US |
dc.title | Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Kuo, Szu-Yu, Adam B. Castoreno, Leslie N. Aldrich, Kara G. Lassen, Gautam Goel, Vlado Dancik, Petric Kuballa, et al. “Small-Molecule Enhancers of Autophagy Modulate Cellular Disease Phenotypes Suggested by Human Genetics.” Proc Natl Acad Sci USA 112, no. 31 (July 20, 2015): E4281–E4287. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.department | Whitehead Institute for Biomedical Research | en_US |
dc.contributor.mitauthor | Jaenisch, Rudolf | en_US |
dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Kuo, Szu-Yu; Castoreno, Adam B.; Aldrich, Leslie N.; Lassen, Kara G.; Goel, Gautam; Dancik, Vlado; Kuballa, Petric; Latorre, Isabel; Conway, Kara L.; Sarkar, Sovan; Maetzel, Dorothea; Jaenisch, Rudolf; Clemons, Paul A.; Schreiber, Stuart L.; Shamji, Alykhan F.; Xavier, Ramnik J. | en_US |
mit.license | PUBLISHER_POLICY | en_US |