Optimizing real time fMRI neurofeedback for therapeutic discovery and development
Name
Gabrieli_Optimizing real time.pdf
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361.41 KB
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Author(s)
Wighton, P.
Greer, S.
Scheinost, D.
Craddock, C.
Calderon, V.
George, M.
Hirshberg, L.
Hampson, M.
Van Der Kouwe, A.
Mackey, S.
Date Issued
July 2014
Journal
NeuroImage: Clinical
Publisher
Elsevier
Citation
Stoeckel, L.E., K.A. Garrison, S.S. Ghosh, P. Wighton, C.A. Hanlon, J.M. Gilman, S. Greer, et al. “Optimizing Real Time fMRI Neurofeedback for Therapeutic Discovery and Development.” NeuroImage: Clinical 5 (2014): 245–255.
Version
Final published version
Abstract
While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health, the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science for an emerging technology, real time functional magnetic resonance imaging (rtfMRI) neurofeedback, in clinical neurotherapeutics. We review the scientific potential of rtfMRI and outline research strategies to optimize the development and application of rtfMRI neurofeedback as a next generation therapeutic tool. We propose that rtfMRI can be used to address a broad range of clinical problems by improving our understanding of brain–behavior relationships in order to develop more specific and effective interventions for individuals with brain disorders. We focus on the use of rtfMRI neurofeedback as a clinical neurotherapeutic tool to drive plasticity in brain function, cognition, and behavior. Our overall goal is for rtfMRI to advance personalized assessment and intervention approaches to enhance resilience and reduce morbidity by correcting maladaptive patterns of brain function in those with brain disorders.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1016/j.nicl.2014.07.002
