| dc.contributor.author | Olenchock, Benjamin | |
| dc.contributor.author | Vander Heiden, Matthew G. | |
| dc.date.accessioned | 2016-08-11T16:08:04Z | |
| dc.date.available | 2016-08-11T16:08:04Z | |
| dc.date.issued | 2013-06 | |
| dc.identifier.issn | 00928674 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/103898 | |
| dc.description.abstract | Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically. | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.cell.2013.06.001 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Pyruvate as a Pivot Point for Oncogene-Induced Senescence | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Olenchock, Benjamin A., and Matthew G. Vander Heiden. “Pyruvate as a Pivot Point for Oncogene-Induced Senescence.” Cell 153, no. 7 (June 2013): 1429–1430. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Olenchock, Benjamin | en_US |
| dc.contributor.mitauthor | Vander Heiden, Matthew G. | en_US |
| dc.relation.journal | Cell | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Olenchock, Benjamin A.; Vander Heiden, Matthew G. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-8956-5117 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-6702-4192 | |
| mit.license | PUBLISHER_CC | en_US |
| mit.metadata.status | Complete | |
