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Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

dc.contributor.authorMihaylova, Maria M.
dc.contributor.authorSabatini, David M.
dc.contributor.authorYilmaz, Omer
dc.contributor.authorMihaylova, Maria M.
dc.contributor.authorSabatini, David
dc.date.accessioned2016-08-22T20:50:02Z
dc.date.available2016-08-22T20:50:02Z
dc.date.issued2014-03
dc.identifier.issn19345909
dc.identifier.urihttp://hdl.handle.net/1721.1/103962
dc.description.abstractOrganismal diet has a profound impact on tissue homeostasis and health in mammals. Adult stem cells are a keystone of tissue homeostasis that alters tissue composition by balancing self-renewal and differentiation divisions. Because somatic stem cells may respond to shifts in organismal physiology to orchestrate tissue remodeling and some cancers are understood to arise from transformed stem cells, there is a likely possibility that organismal diet, stem cell function, and cancer initiation are interconnected. Here we will explore the emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth.en_US
dc.description.sponsorshipDamon Runyon Cancer Research Foundation (DRG-2146-13)en_US
dc.description.sponsorshipHoward Hughes Medical Institute (Investigator)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH CA129105)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH CA103866 award)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH AI047389)en_US
dc.description.sponsorshipDavid H. Koch Institute for Integrative Cancer Research at MIT (Koch Institute Frontier Research Program)en_US
dc.description.sponsorshipLawrence Ellison Foundationen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH/NIA AG045144, K99/ R00 Pathway to Independence Award)en_US
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (CSIBD grant from the NIDDK/NIH (DK043351))en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.stem.2014.02.008en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleDietary and Metabolic Control of Stem Cell Function in Physiology and Canceren_US
dc.typeArticleen_US
dc.identifier.citationMihaylova, Maria M., David M. Sabatini, and Ömer H. Yilmaz. “Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer.” Cell Stem Cell 14, no. 3 (March 2014): 292–305.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorMihaylova, Maria M.en_US
dc.contributor.mitauthorSabatini, David M.en_US
dc.contributor.mitauthorYilmaz, Omeren_US
dc.relation.journalCell Stem Cellen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7577-4612
dc.identifier.orcidhttps://orcid.org/0000-0002-1446-7256
mit.licensePUBLISHER_CCen_US


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