dc.contributor.author | Reizman, Brandon Jacob | |
dc.contributor.author | Wang, Yiming | |
dc.contributor.author | Buchwald, Stephen Leffler | |
dc.contributor.author | Jensen, Klavs F | |
dc.date.accessioned | 2017-02-23T19:00:48Z | |
dc.date.available | 2017-02-23T19:00:48Z | |
dc.date.issued | 2016-10 | |
dc.date.submitted | 2016-08 | |
dc.identifier.issn | 2058-9883 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/107128 | |
dc.description.abstract | An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki–Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to increase the turnover number and yield of the catalytic system considering both discrete variables—palladacycle and ligand—and continuous variables—temperature, time, and loading—simultaneously. The use of feedback allows for experiments to be run with catalysts and under conditions more likely to produce an optimum; consequently complex reaction optimizations are completed within 96 experiments. Response surfaces predicting reaction performance near the optima are generated and validated. From the screening results, shared attributes of successful precatalysts are identified, leading to improved understanding of the influence of ligand selection upon transmetalation and oxidative addition in the reaction mechanism. Dialkylbiarylphosphine, trialkylphosphine, and bidentate ligands are assessed. | en_US |
dc.description.sponsorship | Novartis-MIT Center for Continuous Manufacturing | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (Novartis-MIT Center for Continuous Manufacturing. Grants CHE-9808061 and DBI-9729592) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Postdoctoral Fellowship GM112218) | en_US |
dc.language.iso | en_US | |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1039/c6re00153j | en_US |
dc.rights | Creative Commons Attribution 3.0 Unported license | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | en_US |
dc.source | Royal Society of Chemistry | en_US |
dc.title | Suzuki–Miyaura cross-coupling optimization enabled by automated feedback | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Reizman, Brandon J. et al. “Suzuki–Miyaura Cross-Coupling Optimization Enabled by Automated Feedback.” React. Chem. Eng. 1.6 (2016): 658–666. © 2016 Royal Society of Chemistry | en_US |
dc.contributor.department | Novartis-MIT Center for Continuous Manufacturing | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.mitauthor | Reizman, Brandon Jacob | |
dc.contributor.mitauthor | Wang, Yiming | |
dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
dc.contributor.mitauthor | Jensen, Klavs F | |
dc.relation.journal | Reaction Chemistry & Engineering | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Reizman, Brandon J.; Wang, Yi-Ming; Buchwald, Stephen L.; Jensen, Klavs F. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-6414-0908 | |
dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
dc.identifier.orcid | https://orcid.org/0000-0001-7192-580X | |
mit.license | PUBLISHER_CC | en_US |