Collective antibiotic resistance: mechanisms and implications
Author(s)
Vega, Nicole; Gore, Jeff
DownloadCollective antibiotic resistance.pdf (724.4Kb)
PUBLISHER_CC
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
In collective resistance, microbial communities are able to survive antibiotic exposures that would be lethal to individual cells. In this review, we explore recent advances in understanding collective resistance in bacteria. The population dynamics of ‘cheating’ in a system with cooperative antibiotic inactivation have been described, providing insight into the demographic factors that determine resistance allele frequency in bacteria. Extensive work has elucidated mechanisms underlying collective resistance in biofilms and addressed questions about the role of cooperation in these structures. Additionally, recent investigations of ‘bet-hedging’ strategies in bacteria have explored the contributions of stochasticity and regulation to bacterial phenotypic heterogeneity and examined the effects of these strategies on community survival.
Date issued
2014-09Department
Massachusetts Institute of Technology. Department of PhysicsJournal
Current Opinion in Microbiology
Publisher
Elsevier
Citation
Vega, Nicole M and Gore, Jeff. “Collective Antibiotic Resistance: Mechanisms and Implications.” Current Opinion in Microbiology 21 (October 2014): 28–34. © 2014 Elsevier Ltd
Version: Author's final manuscript
ISSN
1369-5274