| dc.contributor.author | Blackmond, Donna G. | |
| dc.contributor.author | Ruiz-Castillo, Paula | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2017-07-05T14:03:37Z | |
| dc.date.available | 2017-07-05T14:03:37Z | |
| dc.date.issued | 2015-02 | |
| dc.date.submitted | 2014-12 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.issn | 1520-5126 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/110444 | |
| dc.description.abstract | We report the Pd-catalyzed arylation of very hindered α,α,α-trisubstituted primary amines. Kinetics-based mechanistic analysis and rational design have led to the development of two biarylphosphine ligands that allow the transformation to proceed with excellent efficiency. The process was effective in coupling a wide range of functionalized aryl and heteroaryl halides under mild conditions. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (GM5816) | en_US |
| dc.description.sponsorship | Fundación Obra Social de La Caixa (Predoctorate Fellowship) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ja512903g | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Rational Ligand Design for the Arylation of Hindered Primary Amines Guided by Reaction Progress Kinetic Analysis | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Ruiz-Castillo, Paula, Donna G. Blackmond, and Stephen L. Buchwald. “Rational Ligand Design for the Arylation of Hindered Primary Amines Guided by Reaction Progress Kinetic Analysis.” Journal of the American Chemical Society 137.8 (2015): 3085–3092. © 2015 American Chemical Society | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | |
| dc.contributor.mitauthor | Ruiz-Castillo, Paula | |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Ruiz-Castillo, Paula; Blackmond, Donna G.; Buchwald, Stephen L. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-5654-503X | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
