dc.contributor.author | Dong, Yizhou | |
dc.contributor.author | Xue, Kun | |
dc.contributor.author | Weir, Gordon C. | |
dc.contributor.author | Wang, Weiheng | |
dc.contributor.author | Veiseh, Omid | |
dc.contributor.author | Appel, Eric | |
dc.contributor.author | Webber, Matthew | |
dc.contributor.author | Tang, Benjamin C. | |
dc.contributor.author | Yang, Xiwen | |
dc.contributor.author | Langer, Robert S | |
dc.contributor.author | Anderson, Daniel Griffith | |
dc.date.accessioned | 2017-09-06T15:47:20Z | |
dc.date.available | 2017-09-06T15:47:20Z | |
dc.date.issued | 2016-07 | |
dc.date.submitted | 2016-06 | |
dc.identifier.issn | 0743-7463 | |
dc.identifier.issn | 1520-5827 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/111135 | |
dc.description.abstract | Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid–glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10–60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material. | en_US |
dc.description.sponsorship | Leona M. and Harry B. Helmsley Charitable Trust (Award 2014PG-T1D002) | en_US |
dc.description.sponsorship | Juvenile Diabetes Research Foundation International (3-2011-310) | en_US |
dc.description.sponsorship | Juvenile Diabetes Research Foundation International (3-2013-144) | en_US |
dc.description.sponsorship | National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Award F32DK101335) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society (ACS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/acs.langmuir.5b04755 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid–Glucose Complexation | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Dong, Yizhou et al. “Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid–Glucose Complexation.” Langmuir 32, 34 (August 2016): 8743–8747 © 2016 American Chemical Society | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.mitauthor | Wang, Weiheng | |
dc.contributor.mitauthor | Veiseh, Omid | |
dc.contributor.mitauthor | Appel, Eric | |
dc.contributor.mitauthor | Xue, Kun | |
dc.contributor.mitauthor | Webber, Matthew | |
dc.contributor.mitauthor | Tang, Benjamin C. | |
dc.contributor.mitauthor | Yang, Xiwen | |
dc.contributor.mitauthor | Langer, Robert S | |
dc.contributor.mitauthor | Anderson, Daniel Griffith | |
dc.relation.journal | Langmuir | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Dong, Yizhou; Wang, Weiheng; Veiseh, Omid; Appel, Eric A.; Xue, Kun; Webber, Matthew J.; Tang, Benjamin C.; Yang, Xi-Wen; Weir, Gordon C.; Langer, Robert; Anderson, Daniel G. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-3298-6022 | |
dc.identifier.orcid | https://orcid.org/0000-0002-2301-7126 | |
dc.identifier.orcid | https://orcid.org/0000-0003-1561-8762 | |
dc.identifier.orcid | https://orcid.org/0000-0003-0624-3532 | |
dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
dc.identifier.orcid | https://orcid.org/0000-0001-5629-4798 | |
mit.license | PUBLISHER_POLICY | en_US |