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Scalable manufacturing of biomimetic moldable hydrogels for industrial applications

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dc.contributor.author Yu, Anthony C.
dc.contributor.author Chen, Haoxuan
dc.contributor.author Chan, Doreen
dc.contributor.author Agmon, Gillie
dc.contributor.author Stapleton, Lyndsay M.
dc.contributor.author Sevit, Alex M.
dc.contributor.author Acosta, Jesse D.
dc.contributor.author Zhang, Tony
dc.contributor.author Franzia, Paul W.
dc.contributor.author Appel, Eric A.
dc.contributor.author Tibbitt, Mark W
dc.contributor.author Langer, Robert S
dc.date.accessioned 2017-09-13T20:25:42Z
dc.date.available 2017-09-13T20:25:42Z
dc.date.issued 2016-11
dc.date.submitted 2016-09
dc.identifier.issn 0027-8424
dc.identifier.issn 1091-6490
dc.identifier.uri http://hdl.handle.net/1721.1/111205
dc.description.abstract Hydrogels are a class of soft material that is exploited in many, often completely disparate, industrial applications, on account of their unique and tunable properties. Advances in soft material design are yielding next-generation moldable hydrogels that address engineering criteria in several industrial settings such as complex viscosity modifiers, hydraulic or injection fluids, and sprayable carriers. Industrial implementation of these viscoelastic materials requires extreme volumes of material, upwards of several hundred million gallons per year. Here, we demonstrate a paradigm for the scalable fabrication of self-assembled moldable hydrogels using rationally engineered, biomimetic polymer–nanoparticle interactions. Cellulose derivatives are linked together by selective adsorption to silica nanoparticles via dynamic and multivalent interactions. We show that the self-assembly process for gel formation is easily scaled in a linear fashion from 0.5 mL to over 15 L without alteration of the mechanical properties of the resultant materials. The facile and scalable preparation of these materials leveraging self-assembly of inexpensive, renewable, and environmentally benign starting materials, coupled with the tunability of their properties, make them amenable to a range of industrial applications. In particular, we demonstrate their utility as injectable materials for pipeline maintenance and product recovery in industrial food manufacturing as well as their use as sprayable carriers for robust application of fire retardants in preventing wildland fires. en_US
dc.language.iso en_US
dc.publisher National Academy of Sciences (U.S.) en_US
dc.relation.isversionof http://dx.doi.org/10.1073/pnas.1618156113 en_US
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. en_US
dc.source PNAS en_US
dc.title Scalable manufacturing of biomimetic moldable hydrogels for industrial applications en_US
dc.type Article en_US
dc.identifier.citation Yu, Anthony C. et al. “Scalable Manufacturing of Biomimetic Moldable Hydrogels for Industrial Applications.” Proceedings of the National Academy of Sciences 113, 50 (December 2016): 14255–14260 © 2016 National Academy of Sciences en_US
dc.contributor.department David H. Koch Institute for Integrative Cancer Research at MIT en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Chemical Engineering en_US
dc.contributor.mitauthor Tibbitt, Mark W
dc.contributor.mitauthor Langer, Robert S
dc.relation.journal Proceedings of the National Academy of Sciences en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Yu, Anthony C.; Chen, Haoxuan; Chan, Doreen; Agmon, Gillie; Stapleton, Lyndsay M.; Sevit, Alex M.; Tibbitt, Mark W.; Acosta, Jesse D.; Zhang, Tony; Franzia, Paul W.; Langer, Robert; Appel, Eric A. en_US
dspace.embargo.terms N en_US
dc.identifier.orcid https://orcid.org/0000-0002-4917-7187
dc.identifier.orcid https://orcid.org/0000-0003-4255-0492


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