dc.contributor.author | Kong, Wentao | |
dc.contributor.author | Meldgin, David R. | |
dc.contributor.author | Collins, James J. | |
dc.contributor.author | Lu, Ting | |
dc.date.accessioned | 2018-12-05T16:56:28Z | |
dc.date.available | 2018-12-05T16:56:28Z | |
dc.date.issued | 2018-06 | |
dc.date.submitted | 2017-06 | |
dc.identifier.issn | 1552-4450 | |
dc.identifier.issn | 1552-4469 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/119451 | |
dc.description.abstract | Designer microbial consortia are an emerging frontier in synthetic biology that enable versatile microbiome engineering. However, the utilization of such consortia is hindered by our limited capacity in rapidly creating ecosystems with desired dynamics. Here we present the development of synthetic communities through social interaction engineering that combines modular pathway reconfiguration with model creation. Specifically, we created six two-strain consortia, each possessing a unique mode of interaction, including commensalism, amensalism, neutralism, cooperation, competition and predation. These consortia follow distinct population dynamics with characteristics determined by the underlying interaction modes. We showed that models derived from two-strain consortia can be used to design three- and four-strain ecosystems with predictable behaviors and further extended to provide insights into community dynamics in space. This work sheds light on the organization of interacting microbial species and provides a systematic framework—social interaction programming—to guide the development of synthetic ecosystems for diverse purposes. | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (Grant 1553649) | en_US |
dc.description.sponsorship | National Science Foundation (U.S.) (Grant 1227034) | en_US |
dc.description.sponsorship | United States. Office of Naval Research (Award (N00014-16-12525) | en_US |
dc.description.sponsorship | American Cancer Society (Grant 12SDG12090025) | en_US |
dc.description.sponsorship | Defense Threat Reduction Agency (DTRA) (Grant HDTRA1-14-1-0006) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | https://doi.org/10.1038/s41589-018-0091-7 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | Prof. Collins via Howard Silver | en_US |
dc.title | Designing microbial consortia with defined social interactions | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Kong, Wentao et al. “Designing Microbial Consortia with Defined Social Interactions.” Nature Chemical Biology 14, 8 (June 2018): 821–829 | en_US |
dc.contributor.department | Institute for Medical Engineering and Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Synthetic Biology Center | en_US |
dc.contributor.approver | Collins, James J | en_US |
dc.contributor.mitauthor | Collins, James J. | |
dc.relation.journal | Nature Chemical Biology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Kong, Wentao; Meldgin, David R.; Collins, James J.; Lu, Ting | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-5560-8246 | |
mit.license | OPEN_ACCESS_POLICY | en_US |