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Molecular design of conjugated polymers for the control of conformation, electronics and self-assembly
(Massachusetts Institute of Technology, 2008)
The design, synthesis and characterization of organic electronic materials, in particular luminescent conjugated polymers, with structural motifs that allow for the controlled modulation of their photophysical properties ...
Cyclopropene polymerization and enyne metathesis catalyzed by high oxidation state molybdenum alkylidenes
(Massachusetts Institute of Technology, 2008)
Chapter 1. An olefin metathesis reaction between Mo(NAr)(CHCMe2Ph)(OCMe(CF3)2)2 (Ar = 2,6diisopropylphenyl) and trans-i 1,4-divinylbenzene or trans, trans- 1,4-di-buta- 1,3-dienylbenzene (5) results in the formation of ...
An experimental study of OH uptake by surfaces of tropospheric importance under dry and wet conditions
(Massachusetts Institute of Technology, 2008)
The effect of relative humidity (RH) on OH uptake by surfaces of tropospheric importance was investigated. Due to diffusion limitation conditions, experiments were performed with parallel reactors packed with beads and ...
Addition and recombination reactions of unsaturated radicals using a novel laser kinetics spectrometer
(Massachusetts Institute of Technology, 2008)
This thesis describes the construction of a novel, low-noise laser kinetics spectrometer. A quasi-CW (picosecond pulse), tunable Ti:Sapphire laser is used to detect various transient species in laser flash photolysis ...
Tandem benzannulation-ring closing metathesis strategy for the synthesis of benzo-fused nitrogen heterocycles ;
(Massachusetts Institute of Technology, 2008)
A tandem benzannulation-ring closing metathesis strategy for the efficient synthesis of benzo-fused nitrogen heterocycles such as dihydroquinolines, benzazepines, and benzazocines has been developed. This strategy is based ...
Ribonucleotide reduction and redox regulation in Archaea : surprising twists on a common theme
(Massachusetts Institute of Technology, 2008)
To study the nucleotide reduction system in Archaea, we have expressed the Archaeoglobus fulgidus gene encoding the adenosylcobalamin (AdoCbl) dependent ribonucleotide reductase (afuRNR) protein. Initial characterization ...
Photo-cross-linking and identification of nuclear proteins that bind to DNA containing a site-specific adduct of cis-[Pt(NH₃)(N-6-aminohexyl)-4-benzophenonamide)CI₂]
(Massachusetts Institute of Technology, 2008)
cis-Diamminedichloroplatinum(II), or cisplatin, is the most successful cancer drug ever discovered. It has been used for over 30 years in the treatment of several types of malignancies, with the highest success rates in ...
Chemistry of carbonaceous aerosols : studies of atmospheric processing and OH-initiated oxidation
(Massachusetts Institute of Technology, 2008)
Carbonaceous aerosols are among the most prevalent yet least understood constituents of the atmosphere, particularly in urban environments. We have performed analyses of field samples and laboratory studies to probe the ...
Screening, synthesis, and applications of "lipidoids", a novel class of molecules developed for the delivery of RNAi therapeutics
(Massachusetts Institute of Technology, 2008)
RNAi therapeutics represent a fundamentally new way of treating disease, permitting the selective abrogation of protein production at the genetic level. As nucleic acids do not readily enter cells, carriers are utilized ...
Structural investigations of hydroxylase proteins and complexes in bacterial multicomponent monooxygenase systems
(Massachusetts Institute of Technology, 2008)
Bacterial multicomponent monooxgenases (BMMs) such as toluene/o-xylene monooxygenase (ToMO), phenol hydroxylase (PH), and soluble methane monooxygenase (sMMO) catalyze hydrocarbon oxidation reactions at a carboxylatebridged ...