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Now showing items 31-40 of 47
Development of lanthanide-binding tags (LBTs) as powerful and versatile peptides for use in studies of proteins and protein interactions
(Massachusetts Institute of Technology, 2008)
To determine the function of proteins of interest, chemical biologists employ their full panoply of techniques, including X-ray crystallography and NMR spectroscopy for structural information, and luminescence spectroscopy ...
The development of new synthetic strategies and methodologies for complex alkaloid total synthesis : a concise synthesis of (+)-chimonanthine, (+)-WIN 64821, (-)-ditryptophenaline and related alkaloids
(Massachusetts Institute of Technology, 2008)
I. The Development of a General Strategy Towards Dimeric Hexahydropyrroloindole Alkaloids. A Concise Total Synthesis of (+)-Chimonanthine, (+)-Folicanthine and (-)Calycanthine. An efficient and convergent strategy for the ...
Recent advances in copper- and palladium-catalyzed carbon-heteroatom and carbon-carbon bond-formation
(Massachusetts Institute of Technology, 2008)
Metal-catalyzed nucleophilic substitution reactions of aryl halides have become one of the most valuable and useful classes of reactions developed in the last 30 years. Foremost among these processes are the classes of ...
Translocation and proteolysis by the energy-dependent protease ClpAP : coordination of conformational changes and active site chemistry
(Massachusetts Institute of Technology, 2008)
Energy-dependent proteases, such as the E. coli protease ClpAP, degrade misfolded and short-lived regulatory proteins inside the cell. In this class of proteins, an ATPase component (e.g., ClpA) binds, unfolds, and ...
Structure-function studies of agonist binding to the muscle-type nicotinic acetylcholine receptor and the development of a trifunctional non-competitive antagonist suitable for activity-dependent profiling
(Massachusetts Institute of Technology, 2008)
The muscle-type nicotinic acetylcholine receptor (AChR) is a ligand-gated ion channel required for fast synaptic transmission at the neuromuscular junction. It is the archetype of the Cys-Loop superfamily of receptors and ...
Nickel-catalyzed asymmetric cross-couplings of secondary allylic chlorides and planar-chiral compounds in asymmetric synthesis
(Massachusetts Institute of Technology, 2008)
In Part I, nickel-catalyzed asymmetric carbon-carbon bond-forming reactions are described. A nickel/Pybox system effectively catalyzes regio- and enantioselective cross-couplings between racemic secondary allylic chlorides ...
Nanocrystal-molecule energy transfer conjugates for chemical and biological sensing
(Massachusetts Institute of Technology, 2008)
New tools and probes are constantly being developed for chemical and biological sensing. As novel materials emerge, growing demand for sensing in specific applications can be addressed. One such class of materials is ...
Colloidal semiconductor nanocrystals as nanoscale emissive probes in light emitting diodes and cell biology
(Massachusetts Institute of Technology, 2008)
This thesis employs colloidal semiconductor nanocrystals (NCs) as nanoscale emissive probes to investigate the physics of light emitting diodes (LEDs), as well as to unveil properties of cells that conventional imaging ...
Ultrafast dynamic ellipsometry of laser driven shock waves
(Massachusetts Institute of Technology, 2008)
The experimental measurement technique of ultrafast dynamic ellipsometry (UDE) was developed for measuring material motion and changes in optical properties of samples under laser driven shock loading. Ultrafast dynamic ...
Mechanistic investigation of coordinated conformational changes in multisubunit ion channels and enzymes
(Massachusetts Institute of Technology, 2008)
Many enzymes and ion channels consist of multiple subunits and/or multiple distinct functional components. Coordinated conformational changes through allosteric interactions between subunits and/or between functional units ...