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Horizontal gene transfer as a cohesive force in microbial populations
(Massachusetts Institute of Technology, 2017)
Populations are the central unit of evolution and ecology. In the context of evolution, populations are commonly defined as groups of organisms with a shared gene pool in which adaptive genes can spread freely through ...
Mechanisms of CipS reprogramming of the AAA+ protease CipAP
(Massachusetts Institute of Technology, 2016)
The proteome of a cell needs to be constantly modified for protein quality control and to respond to environmental and developmental changes. Energy-dependent proteases are key to ensuring the proper composition of the ...
Molecular organization of the actin cortex in apical constriction and epithelial folding
(Massachusetts Institute of Technology, 2017)
Actin and myosin generate contractile forces to change tissue and cell shape. These shape changes are essential for many biological functions, ranging from muscle contraction to tissue morphogenesis in development. While ...
Investigating the requirement of KRAS for the maintenance of pancreatic cancer
(Massachusetts Institute of Technology, 2016)
Pancreatic cancer, of which 85% is pancreatic ductal adenocarcinoma (PDAC), is the fourth leading cause of cancer death in the United States and a major cause of mortality and morbidity worldwide. Although recent advances ...
0-10 transacetylase : control of synthesis by bacteriophage [epsilon]¹⁵ and substrate specificity of the enzyme
(Massachusetts Institute of Technology, 1966)
Determinants of protein-peptide interaction specificity in the Bcl-2 and TRAF families
(Massachusetts Institute of Technology, 2015)
Protein-peptide interactions have important roles in the majority of cellular processes. There are many families of peptide recognition domains in which homologous members display differential binding preferences for peptide ...
Selectivity in subunit composition of EnaNASP tetramers
(Massachusetts Institute of Technology, 2015)
EnaNASP proteins have an established role in regulating actin dynamics in diverse cell types. The mammalian EnaNASP family members, Mena, VASP, and EVL have many overlapping activities. However, the three family members ...
Haploid reporter screens aimed at identification of NF-kappaB regulators
(Massachusetts Institute of Technology, 2014)
Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...
A molecular characterization of the meiotic initiation factor STRA8 in mice
(Massachusetts Institute of Technology, 2018)
Sexual reproduction requires meiosis, a cellular division program in which one round of DNA replication precedes two rounds of chromosome segregation to produce haploid gametes. In most organisms, accurate meiotic chromosome ...
Regulators of the Drosophila oocyte-to-embryo transition
(Massachusetts Institute of Technology, 2020)
The transition from oocyte to embryo is critical across metazoans, as it marks the onset of development and is essential for fertility. Although many important regulators of the oocyte-to-embryo transition have been ...