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Surface chemistry of N-Heterocyclic carbenes and the self-assembly, structure, and properties of polymer metal-organic cage gels
(Massachusetts Institute of Technology, 2016)
Chapter 1. Introduction to Carbene Ligands in Surface Chemistry: From Stabilization of Discrete Elemental Allotropes to Modification of Nanoscale and Bulk Substrates In this chapter, we review the development of carbene ...
Development and application of new strategies for synthesis of complex diketopiperazine alkaloids
(Massachusetts Institute of Technology, 2018)
I. Quantitative Modeling of Bis(pyridine)silver (I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates The bis(pyridine)silver(I) permanganate promoted ...
Novel palladium precatalysts and their application in cross- coupling reactions and copper-catalyzed enantioselective ring formation
(Massachusetts Institute of Technology, 2015)
Chapters 1 - 3. A series of easily prepared, phosphine-ligated palladium precatalysts based on the 2-aminobiphenyl scaffold have been prepared. The role of the precatalyst-associated labile halide (or pseudohalide) in the ...
Asymmetric nucleophilic catalysis with planar-chiral DMAP derivatives and chiral phosphines : synthetic and mechanistic studies
(Massachusetts Institute of Technology, 2014)
Chapter 1 describes the development and detailed mechanistic investigation of the first non-enzymatic method for the dynamic kinetic resolution of secondary alcohols via enantioselective acylation, with acetyl isopropyl ...
Development of new transition metal-catalyzed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond forming processes
(Massachusetts Institute of Technology, 2018)
Chapter 1. Palladium-Catalyzed Fluorination of Cyclic Vinyl Triflates: Dramatic Effect of TESCF₃ as an Additive A method for the synthesis of cyclic vinyl fluorides with high levels of regiochemical fidelity has been ...
Mechanistic investigation of the interrupted Bischler-Napieralski reaction and its application to the total synthesis of the aspidosperma alkaloids
(Massachusetts Institute of Technology, 2017)
I. Direct Observation of Intermediates Involved in the Interruption of the Bischler- Napieralski Reaction. The first mechanistic investigation of electrophilic amide activation of [alpha], [alpha]-disubstituted tertiary ...
Novel methods and syntheses toward HIV/AIDS and tuberculosis pharmaceuticals
(Massachusetts Institute of Technology, 2017)
[chemical formula] Described herein is a novel Lewis acid catalyzed rearrangement-coupling of oxygen heterocycles and bis(diethylamino)chlorophosphine that provides direct formation of the phosphonomethyl ether functionality ...
Enabling the use of unstable, hazardous reagents with continuous flow synthesis
(Massachusetts Institute of Technology, 2018)
[chemical formula] Highly functionalized 2-arylindoles were synthesized from 2-alkenylarylisocyanides and arylboronic acids using a simple, inexpensive copper catalyst. The reaction exhibits excellent functional group ...
Palladium-catalyzed C-N and C-O cross-coupling reactions
(Massachusetts Institute of Technology, 2016)
Chapter 1: This chapter describes a general method for the of the Pd-catalyzed N-arylation of hindered [alpha],[alpha],[alpha]-trisubstituted primary amines. The reaction utilized catalysts based on two biaryl phosphine ...
New reactivity and selectivity in transition metal-catalyzed C-C and C-N bond forming processes
(Massachusetts Institute of Technology, 2015)
Part I. Palladium-Catalyzed Carbon-Carbon Bond Forming Cross-Couplings Chapter 1. Ligand-Controlled Palladium-Catalyzed Regiodivergent Suzuki-Miyaura Cross-Coupling of Allylboronates and Aryl Halides An orthogonal set of ...