E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6
Author(s)
Hazan, Renin; Mori, Munemasa; Danielian, Paul S; Guen, Vincent J; Rubin, Seth M; Cardoso, Wellington V; Lees, Jacqueline A; ... Show more Show less![Thumbnail](/bitstream/handle/1721.1/146881/mbc.e21-01-0039.pdf.jpg?sequence=4&isAllowed=y)
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<jats:p> Multiciliogenesis requires both nuclear and cytoplasmic functions of the E2F4 transcription factor. Here we identify a domain in E2F4 that interacts with two key components of the cytoplasmic centriole replication machinery, Deup1 and SAS6, and is sufficient to mediate E2F4’s cytoplasmic role in multiciliogenesis. </jats:p>
Date issued
2021Department
Massachusetts Institute of Technology. Department of BiologyJournal
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Citation
Hazan, Renin, Mori, Munemasa, Danielian, Paul S, Guen, Vincent J, Rubin, Seth M et al. 2021. "E2F4’s cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6." Molecular Biology of the Cell, 32 (20).
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