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dc.contributor.authorvan Gool, Kevin CA
dc.contributor.authorCollin, Guusje
dc.contributor.authorBauer, Clemens CC
dc.contributor.authorMolokotos, Elena
dc.contributor.authorMesholam-Gately, Raquelle I
dc.contributor.authorThermenos, Heidi W
dc.contributor.authorSeidman, Larry J
dc.contributor.authorGabrieli, John DE
dc.contributor.authorWhitfield-Gabrieli, Susan
dc.contributor.authorKeshavan, Matcheri S
dc.date.accessioned2023-03-28T18:51:59Z
dc.date.available2023-03-28T18:51:59Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/1721.1/148833
dc.description.abstractBACKGROUND: Schizophrenia spectrum disorders are heritable illnesses that usually manifest in early adulthood but are increasingly viewed as neurodevelopmental disorders. Functional magnetic resonance imaging (fMRI) studies show altered brain activity during performance of working memory (WM) tasks in both individuals with schizophrenia and their first-degree relatives as compared to healthy controls (HC). This study examined whether similar changes are already present in pre-adolescent children at familial high-risk (FHR) for psychosis. METHODS: 37 children (17 FHR, 20 HC) between 7 and 12 years old participated in this study. WM performance was assessed using the Wechsler Intelligence Scale for Children-IV (WISC-IV). To assess brain activation during WM performance, participants completed a visual block-designed n-back task with 2 conditions (2-back and 0-back) during scanning. fMRI data was preprocessed and analyzed using FSL Feat. RESULTS: Compared to HC, FHR children showed significantly lower WISC-IV WM scores. In addition, FHR children exhibited hypoactivation in the 2-back (versus 0-back) condition in a cluster encompassing bilateral precuneus and cuneus and right posterior cingulate cortex. There were no significant group-differences in n-back task performance and brain activation. The precuneus cluster was not correlated with n-back performance or WISC WM scores. CONCLUSIONS: The current results provide preliminary evidence of impaired WM function and altered brain activity during WM performance in children with a familial predisposition for psychosis. Longitudinal studies are needed to determine whether these findings are related to abnormal brain development and predictive of cognitive deficits and psychosis later in life.en_US
dc.language.isoen
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/J.SCHRES.2021.12.030en_US
dc.rightsCreative Commons Attribution 4.0 International licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceElsevieren_US
dc.titleAltered working memory-related brain activity in children at familial high risk for psychosis: A preliminary studyen_US
dc.typeArticleen_US
dc.identifier.citationvan Gool, Kevin CA, Collin, Guusje, Bauer, Clemens CC, Molokotos, Elena, Mesholam-Gately, Raquelle I et al. 2022. "Altered working memory-related brain activity in children at familial high risk for psychosis: A preliminary study." Schizophrenia Research, 240.
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.relation.journalSchizophrenia Researchen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2023-03-28T18:43:20Z
dspace.orderedauthorsvan Gool, KCA; Collin, G; Bauer, CCC; Molokotos, E; Mesholam-Gately, RI; Thermenos, HW; Seidman, LJ; Gabrieli, JDE; Whitfield-Gabrieli, S; Keshavan, MSen_US
dspace.date.submission2023-03-28T18:43:22Z
mit.journal.volume240en_US
mit.licensePUBLISHER_CC
mit.metadata.statusAuthority Work and Publication Information Neededen_US


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