Browsing MIT Open Access Articles by Author "Taatjes, Dylan J."

Now showing items 1-4 of 4

    • Mediator and cohesin connect gene expression and chromatin architecture 

      Kagey, Michael H.; Newman, Jamie Jennifer; Bilodeau, Steve; Zhan, Ye; Orlando, David A.; e.a. (Nature Publishing Group, 2010-08)
      Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound ...

    • Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes 

      Zamudio Montes de Oca, Alicia; Dall’Agnese, Alessandra; Henninger, Jonathan E.; Manteiga, John Colonnese; Afeyan, Lena K.; e.a. (Elsevier BV, 2019-12)
      The gene expression programs that define the identity of each cell are controlled by master transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, which bring extracellular stimuli ...

    • Partitioning of cancer therapeutics in nuclear condensates 

      Klein, Isaac A.; Boija, Ann; Afeyan, Lena K.; Hawken, Susana Wilson; Fan, Mengyang; e.a. (American Association for the Advancement of Science (AAAS), 2020-06)
      © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works The nucleus contains diverse phase-separated condensates that ...

    • Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains 

      Klein, Isaac A.; Sabari, Benjamin R.; Dall’Agnese, Alessandra; Coffey, Eliot L.; Zamudio, Alicia V.; e.a. (Elsevier BV, 2018-12)
      Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ...