Browsing MIT Open Access Articles by Title
Now showing items 10912-10931 of 55842
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Design of Haptic Interfaces for Therapy
(Association for Computing Machinery, 2009-04)Touch is fundamental to our emotional well-being. Medical science is starting to understand and develop touch-based therapies for autism spectrum, mood, anxiety and borderline disorders. Based on the most promising touch ... -
Design of high-speed phase-only spatial light modulators with two-dimensional tunable microcavity arrays
(The Optical Society, 2019-10)Spatial light modulators (SLMs) are central to numerous applications ranging from high-speed displays to adaptive optics, structured illumination microscopy, and holography. After decades of advances, SLM arrays based on ... -
Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variants
(Public Library of Science (PLoS), 2022-09)<jats:p>The rise of SARS-CoV-2 variants and the history of outbreaks caused by zoonotic coronaviruses point to the need for next-generation vaccines that confer protection against variant strains. Here, we combined analyses ... -
Design of immunogens to elicit broadly neutralizing antibodies against HIV targeting the CD4 binding site
(Proceedings of the National Academy of Sciences, 2021)A vaccine which is effective against the HIV virus is considered to be the best solution to the ongoing global HIV/AIDS epidemic. In the past thirty years, numerous attempts to develop an effective vaccine have been made ... -
Design of Insulin-Loaded Nanoparticles Enabled by Multistep Control of Nanoprecipitation and Zinc Chelation
(American Chemical Society (ACS), 2017-04)Nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have potential to address challenges such as effective oral delivery of insulin. However, due to the difficulty of efficiently ... -
Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens
(Multidisciplinary Digital Publishing Institute, 2021-08-31)Rapid detection of bacteria is a very critical and important part of infectious disease treatment. Sepsis kills more than 25 percent of its victims, resulting in as many as half of all deaths in hospitals before identifying ... -
Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens
(Multidisciplinary Digital Publishing Institute, 2021-08-31)Rapid detection of bacteria is a very critical and important part of infectious disease treatment. Sepsis kills more than 25 percent of its victims, resulting in as many as half of all deaths in hospitals before identifying ... -
Design of Inverted Nano-Cone Arrayed SERS Substrate for Rapid Detection of Pathogens
(Multidisciplinary Digital Publishing Institute, 2021-08-31)Rapid detection of bacteria is a very critical and important part of infectious disease treatment. Sepsis kills more than 25 percent of its victims, resulting in as many as half of all deaths in hospitals before identifying ... -
Design of Li[subscript 1+2x]Zn[subscript 1−x]PS[subscript 4], a New Lithium Ion Conductor
(Royal Society of Chemistry, 2016-09)Recent theoretical work has uncovered that a body-centered-cubic (bcc) anion arrangement leads to high ionic conductivity in a number of fast lithium-ion conducting materials. Using this structural feature as a screening ... -
Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination
(American Chemical Society (ACS), 2014-07)Immunization strategies that elicit antibodies capable of neutralizing diverse virus strains will likely be an important part of a successful vaccine against HIV. However, strategies to promote robust humoral responses ... -
Design of lipid nanoparticle delivery agents for multivalent display of recombinant Env trimers in HIV vaccination
(BioMed Central Ltd., 2012-09)Background: Immunization strategies that elicit antibodies capable of neutralizing diverse strains of the virus will likely be an important part of a successful vaccine against HIV. The envelope trimer is the only ... -
Design of Low-Voltage Digital Building Blocks and ADCs for Energy-Efficient Systems
(Institute of Electrical and Electronics Engineers (IEEE), 2012-08)Increasing number of energy-limited applications continue to drive the demand for designing systems with high energy efficiency. This tutorial covers the main building blocks of a system implementation including digital ... -
Design of Mechanism and Preliminary Field Validation of Low-Cost Transfemoral Rotator for Use in the Developing World
(ASME International, 2016-08)Copyright © 2016 by ASME. Transfemoral (above-knee) amputees face a unique and challenging set of restrictions to movement and function. Most notably, they are unable to medially rotate their lower-leg and subsequently ... -
Design of Mechanism and Preliminary Field Validation of Low-Cost, Passive Prosthetic Knee for Users With Transfemoral Amputation in India
(American Society of Mechanical Engineers, 2015-08)An estimated 230,000 above-knee amputees in India are currently in need of prosthetic care, a majority of them facing severe socio-economic constraints. However, only few passive prosthetic knee devices in the market have ... -
Design of Modified Amine Transfer Reagents Allows the Synthesis of α-Chiral Secondary Amines via CuH-Catalyzed Hydroamination
(American Chemical Society (ACS), 2015-07)The CuH-catalyzed hydroamination of alkenes and alkynes using a silane and an amine transfer reagent represents a simple strategy to access chiral amine products. We have recently reported methods to prepare chiral amines ... -
The design of mutual information as a global correlation quantifier
(MDPI, 2020-03)Using first principles from inference, we design a set of functionals for the purposes of ranking joint probability distributions with respect to their correlations. Starting with a general functional, we impose its desired ... -
Design of Nano-Composites for Ultra-High Strengths and Radiation Damage Tolerance
(Cambridge University Press, 2009-01)The combination of high strength and high radiation damage tolerance in nanolaminate composites can be achieved when the individual layers in these composites are only a few nanometers thick and therefore these materials ... -
Design of nanoslotted photonic crystal waveguide cavities for single nanoparticle trapping and detection
(Institute of Electrical and Electronics Engineers, 2009-08)We design and numerically simulate a photonic crystal waveguide cavity with a nanoslot structure for single nanoparticle trapping. A 135times enhancement of optical gradient trapping force compared to plain waveguide ... -
Design of Near Optimal Decision Rules in Multistage Adaptive Mixed-Integer Optimization
(Institute for Operations Research and the Management Sciences (INFORMS), 2015-04)In recent years, decision rules have been established as the preferred solution method for addressing computationally demanding, multistage adaptive optimization problems. Despite their success, existing decision rules (a) ... -
Design of Neutron Microscopes Equipped with Wolter Mirror Condenser and Objective Optics for High-Fidelity Imaging and Beam Transport
(Multidisciplinary Digital Publishing Institute, 2020-09-27)We present and compare the designs of three types of neutron microscopes for high-resolution neutron imaging. Like optical microscopes, and unlike standard neutron imaging instruments, these microscopes have both condenser ...