Browsing MIT Open Access Articles by Title
Now showing items 25221-25240 of 55906
-
Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma
(BioMed Central Ltd., 2018-05)Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, ... -
Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification
(Elsevier, 2016-12)The cell fate decision between interferon-producing plasmacytoid DC (pDC) and antigen-presenting classical DC (cDC) is controlled by the E protein transcription factor TCF4 (E2-2). We report that TCF4 comprises two ... -
Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
(Elsevier, 2013-12)Parkinson’s disease (PD) is characterized by loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). An association has been reported between PD and exposure to mitochondrial toxins, including ... -
Isolated cell behavior drives the evolution of antibiotic resistance
(Nature Publishing Group, 2015-07)Bacterial antibiotic resistance is typically quantified by the minimum inhibitory concentration (MIC), which is defined as the minimal concentration of antibiotic that inhibits bacterial growth starting from a standard ... -
Isolated nano-tendril bundles on tungsten surfaces exposed to radiofrequency helium plasma
(Elsevier BV, 2017-05)The DIONISOS experiment is used to study the impact of RF helium (He) plasma on the surface morphology of tungsten (W) at a frequency of 13.56 MHz. Helium ion energy distributions with a span of 70–75 eV, while still below ... -
Isolating mitotic and meiotic germ cells from male mice by developmental synchronization, staging, and sorting
(Elsevier BV, 2018-08)Isolating discrete populations of germ cells from the mouse testis is challenging, because the adult testis contains germ cells at every step of spermatogenesis, in addition to somatic cells. We present a novel method for ... -
Isolation and Characterization of Bacteria That Degrade Phosphonates in Marine Dissolved Organic Matter
(Frontiers Research Foundation, 2017-09)Semi-labile dissolved organic matter (DOM) accumulates in surface waters of the oligotrophic ocean gyres and turns over on seasonal to annual timescales. This reservoir of DOM represents an important source of carbon, ... -
Isolation and retrieval of circulating tumor cells using centrifugal forces
(Nature Publishing Group, 2013-02)Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral microchannel with inherent centrifugal ... -
Isolation of a Campylobacter lanienae-like Bacterium from Laboratory Chinchillas (Chinchilla laniger)
(Wiley Blackwell, 2014-03)Routine necropsies of 27 asymptomatic juvenile chinchillas revealed a high prevalence of gastric ulcers with microscopic lymphoplasmacytic gastroenteritis and typhlocolitis. Polymerase chain reaction (PCR) analysis using ... -
Isolation of an elusive phosphatetrahedrane
(American Association for the Advancement of Science (AAAS), 2020-03)This exploratory synthesis investigation was undertaken to determine the viability of replacing a single carbon vertex with another p-block element in a highly strained tetrahedrane molecule. Phosphorus was selected for ... -
Isolation of Circulating Plasma Cells in Multiple Myeloma Using CD138 Antibody-Based Capture in a Microfluidic Device
(Nature Publishing Group, 2017-04)The necessity for bone marrow aspiration and the lack of highly sensitive assays to detect residual disease present challenges for effective management of multiple myeloma (MM), a plasma cell cancer. We show that a ... -
Isolation of cuspidal spectrum, with application to the Gan–Gross–Prasad conjecture
(Annals of Mathematics, 2021) -
Isolation of exosomes from whole blood by integrating acoustics and microfluidics
(National Academy of Sciences (U.S.), 2017-09)Exosomes are nanoscale extracellular vesicles that play an important role in many biological processes, including intercellular communications, antigen presentation, and the transport of proteins, RNA, and other molecules. ... -
Isolation of flow and nonflow correlations by two- and four-particle cumulant measurements of azimuthal harmonics in √s[subscript NN] = 200 GeV Au+Au collisions
(Elsevier, 2015-04)A data-driven method was applied to Au+Au collisions a t√s[subscript NN] = 200 GeV made with the STAR detector at RHIC to isolate pseudorapidity distance Δη-dependent and Δη-independent correlations by using two- and ... -
Isolation of Pure Disubstituted E Olefins through Mo-Catalyzed Z-Selective Ethenolysis of Stereoisomeric Mixtures
(American Chemical Society, 2011-08)Monoaryloxide–pyrrolide (MAP) complexes of molybdenum were employed for the selective ethenolysis of 1,2-disubstituted Z olefins in the presence of the corresponding E olefins. Reactions were performed in the presence of ... -
Isolation, Development, and Genomic Analysis of Bacillus megaterium SR7 for Growth and Metabolite Production Under Supercritical Carbon Dioxide
(Frontiers Media SA, 2018)Supercritical carbon dioxide (scCO2) is an attractive substitute for conventional organic solvents due to its unique transport and thermodynamic properties, its renewability and labile nature, and its high solubility for ... -
Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells
(Springer Nature America, Inc, 2010-05)Herein, we describe a protocol for the isolation of human embryonic stem cells (hESCs)-derived vascular cells at various stages of development. The cells are isolated from 10 to 15-d-old human embryoid bodies (EBs) cultured ... -
Isomorphisms, automorphisms, and generalized involution models of projective reflection groups
(The Hebrew University Magnes Press, 2013-08)We investigate the generalized involution models of the projective reflection groups G(r, p, q, n). This family of groups parametrizes all quotients of the complex reflection groups G(r, p, n) by scalar subgroups. Our ... -
Isonitrile Formation by a Non-heme Iron(II)-Dependent Oxidase/Decarboxylase
(Wiley, 2018-07)The electron-rich isonitrile is an important functionality in bioactive natural products, but its biosynthesis has been restricted to the IsnA family of isonitrile synthases. We herein provide the first structural and ... -
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
(American Association for the Advancement of Science (AAAS), 2010-09)Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here, we report a multivariate-modular ...
