Browsing MIT Open Access Articles by Title
Now showing items 27952-27971 of 55844
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MALA-within-Gibbs Samplers for High-Dimensional Distributions with Sparse Conditional Structure
(Society for Industrial & Applied Mathematics (SIAM), 2020)© 2020 Society for Industrial and Applied Mathematics. Markov chain Monte Carlo (MCMC) samplers are numerical methods for drawing samples from a given target probability distribution. We discuss one particular MCMC sampler, ... -
Malaria parasite clearance rate regression: an R software package for a Bayesian hierarchical regression model
(BioMed Central, 2019-01)Background Emerging resistance to anti-malarial drugs has led malaria researchers to investigate what covariates (parasite and host factors) are associated with resistance. In this regard, investigation ... -
Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation
(American Society for Microbiology, 2021)<jats:p> <jats:named-content content-type="genus-species">P. falciparum</jats:named-content> is the most virulent malaria parasite species, accounting for the majority of the disease mortality and ... -
MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum
(Elsevier BV, 2021)Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet ... -
Malarial Parasites Accumulate Labile Zinc Pools
(Elsevier, 2012-06)The malarial parasite, Plasmodium falciparum, is an intracellular pathogen and partially dependent on nutrient uptake for survival. In this issue of Chemistry & Biology, Marvin et al. demonstrate that zinc is essential for ... -
MalDA, Accelerating Malaria Drug Discovery
(Elsevier BV, 2021)© 2021 The Authors The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories. The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process by identifying new, ... -
MalDA, Accelerating Malaria Drug Discovery
(Elsevier BV, 2021-02)© 2021 The Authors The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories. The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process by identifying new, ... -
Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding
(Frontiers Research Foundation, 2012-10)Previous functional MRI (fMRI) studies have shown that fragile X mental retardation 1 (FMR1) fragile X premutation allele carriers (FXPCs) exhibit decreased hippocampal activation during a recall task and lower inferior ... -
Male Syrian Hamsters Experimentally Infected with Helicobacter spp. of the H. bilis Cluster Develop MALT-Associated Gastrointestinal Lymphomas
(Wiley Blackwell, 2016-05)Background: Aged hamsters naturally infected with novel Helicobacter spp. classified in the H. bilis cluster develop hepatobiliary lesions and typhlocolitis. Methods: To determine whether enterohepatic H. spp. contribute ... -
Male-Dependent Promotion of Colitis in 129 Rag2−/− Mice Co-Infected with Helicobacter pylori and Helicobacter hepaticus
(MDPI AG, 2020-11)The prevalence of gastric Helicobacter pylori (Hp) infection is ~50% of the world population. However, how Hp infection influences inflammatory bowel disease in humans is not fully defined. In this study, we examined whether ... -
malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication
(Public Library of Science (PLoS), 2017-11)Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication ... -
Males Are Capable of Long-Distance Dispersal in a Social Bee
(Frontiers Media SA, 2022-03-14)Pollinator conservation is aided by knowledge of dispersal behavior, which shapes gene flow and population structure. In many bees, dispersal is thought to be male-biased, and males’ movements may be critical to maintaining ... -
Malicious User Detection in a Cognitive Radio Cooperative Sensing System
(Institute of Electrical and Electronics Engineers, 2011-08)Reliable detection of primary users (PUs) is an important task for cognitive radio (CR) systems. Cooperation among a few spectrum sensors has been shown to offer significant gain in the performance of the CR spectrum-sensing ... -
Malleable coding with edit-distance cost
(Institute of Electrical and Electronics Engineers, 2009-08)A malleable coding scheme considers not only representation length but also ease of representation update, thereby encouraging some form of recycling to convert an old codeword into a new one. We examine the trade-off ... -
Mammalian cell growth dynamics in mitosis
(eLife Sciences Publications, Ltd, 2019-05)The extent and dynamics of animal cell biomass accumulation during mitosis are unknown, primarily because growth has not been quantified with sufficient precision and temporal resolution. Using the suspended microchannel ... -
A mammalian functional-genetic approach to characterizing cancer therapeutics
(Nature Publishing Group, 2010-12)Identifying mechanisms of drug action remains a fundamental impediment to the development and effective use of chemotherapeutics. Here we describe an RNA interference (RNAi)–based strategy to characterize small-molecule ... -
Mammalian germ cells are determined after PGC colonization of the nascent gonad
(Proceedings of the National Academy of Sciences, 2019-12)Mammalian primordial germ cells (PGCs) are induced in the embryonic epiblast, before migrating to the nascent gonads. In fish, frogs, and birds, the germline segregates even earlier, through the action of maternally inherited ... -
Mammalian microRNAs predominantly act to decrease target mRNA levels
(Nature Publishing Group, 2010-06)MicroRNAs (miRNAs) are endogenous ~22-nucleotide RNAs that mediate important gene-regulatory events by pairing to the mRNAs of protein-coding genes to direct their repression. Repression of these regulatory targets leads ... -
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery
(American Association for the Advancement of Science (AAAS), 2021-08-20)Hitching a ride with a retroelement Retroviruses and retroelements have inserted their genetic code into mammalian genomes throughout evolution. Although many of these integrated virus-like sequences pose a threat to ... -
Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery
(Nature Publishing Group, 2015-08)Synthetic regulatory circuits encoded in RNA rather than DNA could provide a means to control cell behavior while avoiding potentially harmful genomic integration in therapeutic applications. We create post-transcriptional ...
