Browsing MIT Open Access Articles by Title
Now showing items 854-873 of 55918
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ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein
(American Society for Biochemistry and Molecular Biology, 2011-09)Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), ... -
An Adaptable k-Nearest Neighbors Algorithm for MMSE Image Interpolation
(Institute of Electrical and Electronics Engineers, 2009-08)We propose an image interpolation algorithm that is nonparametric and learning-based, primarily using an adaptive k-nearest neighbor algorithm with global considerations through Markov random fields. The empirical nature ... -
An Adaptable Platform for Directed Evolution in Human Cells
(American Chemical Society (ACS), 2018-12)The discovery and optimization of biomolecules that reliably function in metazoan cells is imperative for both the study of basic biology and the treatment of disease. We describe the development, characterization, and ... -
An Adaptable Random Forest Model for the Declustering of Earthquake Catalogs
(American Geophysical Union (AGU), 2022-02) -
An Adaptable Random Forest Model for the Declustering of Earthquake Catalogs
(American Geophysical Union (AGU), 2022-02) -
Adaptation and the Boundary of Multinational Firms
(MIT Press, 2011-02)This paper offers the first empirical analysis of the impact of adaptation on the boundary of multinational firms. To do so, we develop a ranking of sectors in terms of “routineness” by merging two sets of data: (i) ratings ... -
Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point-process GLMs
(Frontiers Research Foundation, 2015-04)Currently little is known about how a mechanically coupled BMI system's actions are integrated into ongoing body dynamics. We tested a locomotor task augmented with a BMI system driving a robot mechanically interacting ... -
Adaptation to robot failures and shape change in decentralized
(Institute of Electrical and Electronics Engineers, 2010-07)Our prior work [1] presented a decentralized algorithm for coordinating the construction of a truss structure out of multiple components. In this paper, we discuss adaptation in decentralized construction. We partition ... -
AdaptCast: An integrated source to transmission scheme for wireless sensor networks
(Institute of Electrical and Electronics Engineers (IEEE), 2015-06)This paper introduces AdaptCast, an integrated source to transmission scheme for wireless sensor networks (WSNs) that efficiently represents collected data and increases their robustness against channel errors across a ... -
AdaptDB: Adaptive Partitioning for Distributed Joins
(Association for Computing Machinery (ACM), 2017-01)Big data analytics often involves complex join queries over two or more tables. Such join processing is expensive in a distributed setting both because large amounts of data must be read from disk, and because of data ... -
Adapting DFT+U for the Chemically Motivated Correction of Minimal Basis Set Incompleteness
(American Chemical Society, 2016-07)Recent algorithmic and hardware advances have enabled the application of electronic structure methods to the study of large-scale systems such as proteins with O(103) atoms. Most such methods benefit greatly from the use ... -
Adapting to life at the end of the line: How Drosophila telomeric retrotransposons cope with their job
(Landes Bioscience, 2011-07)Drosophila telomeres are remarkable because they are maintained by telomere-specific retrotransposons, rather than the enzyme telomerase that maintains telomeres in almost every other eukaryotic organism. Successive ... -
Adaptive alternating minimization algorithms
(Institute of Electrical and Electronics Engineers, 2009-02)The classical alternating minimization (or projection) algorithm has been successful in the context of solving optimization problems over two variables. The iterative nature and simplicity of the algorithm has led to its ... -
Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity
(Springer Science and Business Media LLC, 2021)To understand the underlying mechanisms of progressive neurophysiological phenomena, neural interfaces should interact bi-directionally with brain circuits over extended periods of time. However, such interfaces remain ... -
Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells
(American Association for Cancer Research (AACR), 2017-12)Activating mutations in KRAS are the hallmark genetic alterations in pancreatic ductal adenocarcinoma (PDAC) and the key drivers of its initiation and progression. Longstanding efforts to develop novel KRAS inhibitors have ... -
Adaptive and Selective Time Averaging of Auditory Scenes
(Elsevier BV, 2018-04)To overcome variability, estimate scene characteristics, and compress sensory input, perceptual systems pool data into statistical summaries. Despite growing evidence for statistical representations in perception, the ... -
Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need
(Wiley, 2016-09)The current system of biomedical innovation is unable to keep pace with scientific advancements. We propose to address this gap by reengineering innovation processes to accelerate reliable delivery of products that address ... -
Adaptive Causal Network Coding with Feedback
(Institute of Electrical and Electronics Engineers (IEEE), 2020)© 1972-2012 IEEE. We propose a novel adaptive and causal random linear network coding (AC-RLNC) algorithm with forward error correction (FEC) for a point-to-point communication channel with delayed feedback. AC-RLNC is ... -
Adaptive Causal Network Coding with Feedback for Multipath Multi-hop Communications
(Institute of Electrical and Electronics Engineers (IEEE), 2020)© 1972-2012 IEEE. We propose a novel multipath multi-hop adaptive and causal random linear network coding (AC-RLNC) algorithm with forward error correction. This algorithm generalizes our joint optimization coding solution ...