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Targeting of drugs and nanoparticles to tumors

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dc.contributor.author Ruoslahti, Erkki
dc.contributor.author Sailor, Michael J.
dc.contributor.author Bhatia, Sangeeta N.
dc.date.accessioned 2010-09-24T14:59:44Z
dc.date.available 2010-09-24T14:59:44Z
dc.date.issued 2010-03
dc.date.submitted 2009-10
dc.identifier.issn 1540-8140
dc.identifier.issn 0021-9525
dc.identifier.uri http://hdl.handle.net/1721.1/58699
dc.description.abstract The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as docking sites to concentrate drug conjugates and nanoparticles at tumors. Specific markers in tumor vessels are particularly well suited for targeting because molecules at the surface of blood vessels are readily accessible to circulating compounds. The increased concentration of a drug in the site of disease made possible by targeted delivery can be used to increase efficacy, reduce side effects, or achieve some of both. We review the recent advances in this delivery approach with a focus on the use of molecular markers of tumor vasculature as the primary target and nanoparticles as the delivery vehicle. en_US
dc.description.sponsorship United States. Dept. of Defense (grant W81XWH-08-1-0727) en_US
dc.description.sponsorship National Science Foundation (grant DMR-0806859) en_US
dc.description.sponsorship Moores Cancer Center en_US
dc.description.sponsorship NanoTUMOR Center en_US
dc.description.sponsorship National Institutes of Health (U.S.) (grant U54 CA-119335) en_US
dc.description.sponsorship MIT/Harvard Center for Cancer Nanotechnology (grant U54 CA-119349) en_US
dc.description.sponsorship National Cancer Institute (U.S.). Bioengineering Research Partnership (grant CA-122427) en_US
dc.language.iso en_US
dc.publisher Rockefeller University Press en_US
dc.relation.isversionof http://dx.doi.org/10.1083/jcb.200910104 en_US
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. en_US
dc.source MIT Web Domain en_US
dc.title Targeting of drugs and nanoparticles to tumors en_US
dc.type Article en_US
dc.identifier.citation Ruoslahti, Erkki, Sangeeta N. Bhatia, and Michael J. Sailor. “Targeting of drugs and nanoparticles to tumors.” The Journal of Cell Biology 188.6 (2010): 759 -768. en_US
dc.contributor.department Whitaker College of Health Sciences and Technology en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science en_US
dc.contributor.approver Bhatia, Sangeeta N.
dc.contributor.mitauthor Bhatia, Sangeeta N.
dc.relation.journal Journal of Cell Biology en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J. en


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