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Zebrafish promoter microarrays identify actively transcribed embryonic genes

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dc.contributor.author Wardle, Fiona C
dc.contributor.author Odom, Duncan T
dc.contributor.author Bell, George W.
dc.contributor.author Wiellette, Elizabeth L
dc.contributor.author Herbolsheimer, Elizabeth
dc.contributor.author Smith, James C
dc.contributor.author Yuan, Bingbing B.
dc.contributor.author Sive, Hazel L.
dc.contributor.author Danford, Timothy William
dc.contributor.author Young, Richard A.
dc.date.accessioned 2010-10-05T20:08:23Z
dc.date.available 2010-10-05T20:08:23Z
dc.date.issued 2006-08
dc.date.submitted 2006-04
dc.identifier.issn 1474-760X
dc.identifier.issn 1465-6914
dc.identifier.issn 1465-6906
dc.identifier.uri http://hdl.handle.net/1721.1/58880
dc.description.abstract We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation with an antibody directed against tri-methylated lysine 4 of Histone H3, we demonstrate the feasibility of this method in zebrafish. This approach will allow investigators to determine the genomic binding locations of DNA interacting proteins during development and expedite the assembly of the genetic networks that regulate embryogenesis. en_US
dc.description.sponsorship Wellcome Trust en_US
dc.description.sponsorship European Molecular Biology Organization en_US
dc.description.sponsorship National Institutes of Health (Grant HG002668) (Grant DK070813) (Grant 2RO1 HD33472) (Grant 5RO1 MH59942) en_US
dc.publisher BioMed Central Ltd en_US
dc.relation.isversionof http://dx.doi.org/10.1186/gb-2006-7-8-r71 en_US
dc.rights Creative Commons Attribution en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.source BioMed Central Ltd en_US
dc.title Zebrafish promoter microarrays identify actively transcribed embryonic genes en_US
dc.type Article en_US
dc.identifier.citation Genome Biology. 2006 Aug 04;7(8):R71 en_US
dc.contributor.department Whitehead Institute for Biomedical Research en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biology en_US
dc.contributor.department Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory en_US
dc.contributor.mitauthor Yuan, Bingbing B.
dc.contributor.mitauthor Sive, Hazel L.
dc.contributor.mitauthor Danford, Timothy William
dc.contributor.mitauthor Young, Richard A.
dc.contributor.mitauthor Bell, George W.
dc.relation.journal Genome Biology en_US
dc.identifier.mitlicense PUBLISHER_CC en_US
dc.eprint.version Final published version en_US
dc.identifier.pmid 16889661
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dc.date.updated 2010-09-03T16:14:25Z
dc.language.rfc3066 en
dc.rights.holder Wardle et al.; licensee BioMed Central Ltd.
dspace.orderedauthors Wardle, Fiona C; Odom, Duncan T; Bell, George W; Yuan, Bingbing; Danford, Timothy W; Wiellette, Elizabeth L; Herbolsheimer, Elizabeth; Sive, Hazel L; Young, Richard A; Smith, James C en


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