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Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography

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dc.contributor.author Choma, Michael A.
dc.contributor.author Suter, Melissa J.
dc.contributor.author Vakoc, Benjamin
dc.contributor.author Bouma, Brett E.
dc.contributor.author Tearney, Guillermo J.
dc.date.accessioned 2011-06-29T20:05:45Z
dc.date.available 2011-06-29T20:05:45Z
dc.date.issued 2010-09
dc.date.submitted 2010-08
dc.identifier.issn 1083-3668
dc.identifier.uri http://hdl.handle.net/1721.1/64711
dc.description.abstract Drosophila melanogaster (fruit fly) is a central organism in biology and is becoming increasingly important in the cardiovascular sciences. Prior work in optical imaging of the D. melanogaster heart has focused on static and dynamic structural anatomy. In the study, it is demonstrated that Doppler optical coherence tomography can quantify dynamic heart wall velocity and hemolymph flow in adult D. melanogaster. Since hemolymph is optically transparent, a novel exogenous contrast technique is demonstrated to increase the backscatter-based intracardiac Doppler flow signal. The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster. en_US
dc.description.sponsorship Frederick H. Lovejoy Fund en_US
dc.description.sponsorship Children's Hospital (Boston, Mass.) en_US
dc.description.sponsorship AMA Foundation en_US
dc.description.sponsorship AMA Foundation (Seed Grant) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (NIH R01HL076398) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (NIH R01HL076398) en_US
dc.description.sponsorship United States. Air Force Office of Scientific Research (Medical Free Electron Laser Program FA9550-04-1-0079) en_US
dc.language.iso en_US
dc.publisher Society of Photo-optical Instrumentation Engineers en_US
dc.relation.isversionof http://dx.doi.org/10.1117/1.3503418 en_US
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. en_US
dc.source SPIE en_US
dc.title Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography en_US
dc.type Article en_US
dc.identifier.citation Choma, Michael A. et al. “Heart Wall Velocimetry and Exogenous Contrast-based Cardiac Flow Imaging in Drosophila Melanogaster Using Doppler Optical Coherence Tomography.” Journal of Biomedical Optics 15.5 (2010) : 056020-6. © 2010 SPIE. en_US
dc.contributor.department Harvard University--MIT Division of Health Sciences and Technology en_US
dc.contributor.approver Tearney, Guillermo J.
dc.contributor.mitauthor Tearney, Guillermo J.
dc.contributor.mitauthor Vakoc, Benjamin
dc.contributor.mitauthor Bouma, Brett E.
dc.relation.journal Journal of Biomedical Optics en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Choma, Michael A.; Suter, Melissa J.; Vakoc, Benjamin J.; Bouma, Brett E.; Tearney, Guillermo J. en


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