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Positive outcomes of oil palm phenolics on degenerative diseases in animal models

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dc.contributor.author Sambanthamurthi, Ravigadevi
dc.contributor.author Tan, YewAi
dc.contributor.author Sundram, Kalyana
dc.contributor.author Hayes, Kenneth C.
dc.contributor.author Abeywardena, Mahinda
dc.contributor.author Leow, Soon-Sen
dc.contributor.author Sekaran, Shamala Devi
dc.contributor.author Sambandan, T. G.
dc.contributor.author Rha, ChoKyun
dc.contributor.author Sinskey, Anthony J.
dc.contributor.author Subramaniam, Krishnan
dc.contributor.author Fairus, Syed
dc.contributor.author Wahid, Mohd Basri
dc.date.accessioned 2012-11-13T16:07:52Z
dc.date.available 2012-11-13T16:07:52Z
dc.date.issued 2011-06
dc.date.submitted 2011-03
dc.identifier.issn 0007-1145
dc.identifier.issn 1475-2662
dc.identifier.uri http://hdl.handle.net/1721.1/74627
dc.description.abstract It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals. en_US
dc.language.iso en_US
dc.publisher Cambridge University Press en_US
dc.relation.isversionof http://dx.doi.org/10.1017/S0007114511002133 en_US
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. en_US
dc.source MIT web domain en_US
dc.title Positive outcomes of oil palm phenolics on degenerative diseases in animal models en_US
dc.type Article en_US
dc.identifier.citation Sambanthamurthi, Ravigadevi et al. “Positive Outcomes of Oil Palm Phenolics on Degenerative Diseases in Animal Models.” British Journal of Nutrition 106.11 (2011): 1664–1675. © Cambridge University Press 2011 en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Biology en_US
dc.contributor.department Massachusetts Institute of Technology. Office of the Provost en_US
dc.contributor.department Massachusetts Institute of Technology. Biomaterials Science and Engineering Laboratory en_US
dc.contributor.mitauthor Sambandan, T. G.
dc.contributor.mitauthor Rha, ChoKyun
dc.contributor.mitauthor Sinskey, Anthony J.
dc.relation.journal British Journal of Nutrition en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Sambanthamurthi, Ravigadevi; Tan, YewAi; Sundram, Kalyana; Hayes, Kenneth C.; Abeywardena, Mahinda; Leow, Soon-Sen; Devi Sekaran, Shamala; Sambandan, T. G.; Rha, ChoKyun; Sinskey, Anthony J.; Subramaniam, Krishnan; Fairus, Syed; Basri Wahid, Mohd en


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