| dc.contributor.author | Webb, Damien | |
| dc.contributor.author | Jamison, Timothy F. | |
| dc.date.accessioned | 2013-01-17T18:18:32Z | |
| dc.date.available | 2013-01-17T18:18:32Z | |
| dc.date.issued | 2012-04 | |
| dc.date.submitted | 2012-03 | |
| dc.identifier.issn | 1523-7060 | |
| dc.identifier.issn | 1523-7052 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/76285 | |
| dc.description.abstract | A continuous protocol for the two-carbon homologation of esters to α,β-unsaturated esters is described. This multireactor homologation telescopes an ester reduction, phosphonate deprotonation, and Horner–Wadsworth–Emmons olefination, thus converting a three-operation procedure into a single, uninterrupted system that eliminates the need for isolation or purification of the aldehyde intermediates. The homologated products are obtained in high yield and selectivity. | en_US |
| dc.description.sponsorship | Novartis-MIT Center for Continuous Manufacturing | en_US |
| dc.language.iso | en_US | |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/ol300722e | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Prof. Jamison via Erja Kajosalo | en_US |
| dc.title | A Continuous Homologation of Esters: An Efficient Telescoped Reduction–Olefination Sequence | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Webb, Damien, and Timothy F. Jamison. “A Continuous Homologation of Esters: An Efficient Telescoped Reduction–Olefination Sequence.” Organic Letters 14.10 (2012): 2465–2467. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.approver | Jamison, Timothy F. | |
| dc.contributor.mitauthor | Webb, Damien | |
| dc.contributor.mitauthor | Jamison, Timothy F. | |
| dc.relation.journal | Organic Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Webb, Damien; Jamison, Timothy F. | en |
| dc.identifier.orcid | https://orcid.org/0000-0002-8601-7799 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
