Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides

Author(s)
Biscoe, Mark R.; Buchwald, Stephen Leffler
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Abstract
Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method was available to ensure the highly selective monoarylation of these classes of substrates using aryl chlorides. Using palladium precatalysts recently reported by our group, these reactions are easily accomplished under mild conditions that tolerate a wide array of heterocyclic substrates.
Date issued
2009-03
URI
http://hdl.handle.net/1721.1/82105
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Biscoe, Mark R., and Stephen L. Buchwald. “Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides.” Organic Letters 11, no. 8 (April 16, 2009): 1773-1775.
Version: Author's final manuscript
ISSN
1523-7060
1523-7052
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