| dc.contributor.author | Hynes, Richard O | |
| dc.date.accessioned | 2014-01-27T17:14:08Z | |
| dc.date.available | 2014-01-27T17:14:08Z | |
| dc.date.issued | 2011-12 | |
| dc.identifier.issn | 15356108 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/84580 | |
| dc.description.abstract | Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth. | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/j.ccr.2011.11.022 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | Elsevier Open Archive | en_US |
| dc.title | Metastatic Cells Will Take Any Help They Can Get | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Hynes, Richard O. “Metastatic Cells Will Take Any Help They Can Get.” Cancer Cell 20, no. 6 (December 2011): 689-690. Copyright © 2011 Elsevier Inc. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Hynes, Richard O. | en_US |
| dc.relation.journal | Cancer Cell | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Hynes, Richard O. | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-7603-8396 | |
| mit.license | PUBLISHER_POLICY | en_US |
| mit.metadata.status | Complete | |
