dc.contributor.author | Engreitz, Jesse Michael | |
dc.contributor.author | Pandya-Jones, Amy | |
dc.contributor.author | McDonel, Patrick | |
dc.contributor.author | Shishkin, Alexander | |
dc.contributor.author | Sirokman, Klara | |
dc.contributor.author | Surka, Christine | |
dc.contributor.author | Kadri, Sabah | |
dc.contributor.author | Xing, Jeffrey | |
dc.contributor.author | Goren, Alon | |
dc.contributor.author | Plath, Kathrin | |
dc.contributor.author | Guttman, Mitchell | |
dc.contributor.author | Lander, Eric Steven | |
dc.date.accessioned | 2014-03-10T16:25:57Z | |
dc.date.available | 2014-03-10T16:25:57Z | |
dc.date.issued | 2013-07 | |
dc.date.submitted | 2013-03 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.issn | 1095-9203 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/85575 | |
dc.description.abstract | Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maintenance of XCI, Xist binds broadly across the X chromosome. During initiation of XCI, Xist initially transfers to distal regions across the X chromosome that are not defined by specific sequences. Instead, Xist identifies these regions by exploiting the three-dimensional conformation of the X chromosome. Xist requires its silencing domain to spread across actively transcribed regions and thereby access the entire chromosome. These findings suggest a model in which Xist coats the X chromosome by searching in three dimensions, modifying chromosome structure, and spreading to newly accessible locations. | en_US |
dc.description.sponsorship | Hertz Foundation | en_US |
dc.description.sponsorship | American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowship | en_US |
dc.description.sponsorship | Broad Institute of MIT and Harvard | en_US |
dc.language.iso | en_US | |
dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1126/science.1237973 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Engreitz, J. M., A. Pandya-Jones, P. McDonel, A. Shishkin, K. Sirokman, C. Surka, S. Kadri, et al. “The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome.” Science 341, no. 6147 (August 16, 2013): 1237973–1237973. | en_US |
dc.contributor.department | Whitaker College of Health Sciences and Technology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.mitauthor | Engreitz, Jesse Michael | en_US |
dc.contributor.mitauthor | Lander, Eric S. | en_US |
dc.relation.journal | Science | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Engreitz, J. M.; Pandya-Jones, A.; McDonel, P.; Shishkin, A.; Sirokman, K.; Surka, C.; Kadri, S.; Xing, J.; Goren, A.; Lander, E. S.; Plath, K.; Guttman, M. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-5754-1719 | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |