dc.contributor.author | Peca, Joao | |
dc.contributor.author | Feliciano, Catia | |
dc.contributor.author | Ting, Jonathan T. | |
dc.contributor.author | Wang, Wenting | |
dc.contributor.author | Wells, Michael F. | |
dc.contributor.author | Venkatraman, Talaignair N. | |
dc.contributor.author | Lascola, Christopher D. | |
dc.contributor.author | Fu, Zhanyan | |
dc.contributor.author | Feng, Guoping | |
dc.date.accessioned | 2014-06-09T15:02:16Z | |
dc.date.available | 2014-06-09T15:02:16Z | |
dc.date.issued | 2011-03 | |
dc.date.submitted | 2010-09 | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.issn | 1476-4687 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/87697 | |
dc.description.abstract | Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by widespread abnormalities in social interactions, deficits in communication as well as restricted interests and repetitive behaviours. The neurological basis and circuitry mechanisms underlying these abnormal behaviours are poorly understood. SHANK3 is a postsynaptic protein, whose disruption at the genetic level is thought to be responsible for the development of 22q13 deletion syndrome (Phelan–McDermid syndrome) and other non-syndromic ASDs. Here we show that mice with Shank3 gene deletions exhibit self-injurious repetitive grooming and deficits in social interaction. Cellular, electrophysiological and biochemical analyses uncovered defects at striatal synapses and cortico-striatal circuits in Shank3 mutant mice. Our findings demonstrate a critical role for SHANK3 in the normal development of neuronal connectivity and establish causality between a disruption in the Shank3 gene and the genesis of autistic-like behaviours in mice. | en_US |
dc.description.sponsorship | National Institute of Mental Health (U.S.) (NIMH/NIH (R01MH081201)) | en_US |
dc.description.sponsorship | Hartwell Foundation (Hartwell Individual Biomedical Research Award) | en_US |
dc.description.sponsorship | Simons Foundation (Autism Research Initiative (SFARI) grant Award) | en_US |
dc.description.sponsorship | Brain and Behavior Research Foundation (NARSAD Young Investigator Award) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award (F32MH084460)) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (NIH grant (R03MH085224)) | en_US |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia (SFRH/BD/15231/2004) | en_US |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia (SFRH/BD/15855/2005) | en_US |
dc.description.sponsorship | Instituto Gulbenkian de Ciência (“Programa Gulbenkian de Doutoramento em Biomedicina” (PGDB, Oeiras, Portugal)) | en_US |
dc.description.sponsorship | University of Coimbra. Center for Neuroscience and Cell Biology (“Programa Doutoral em Biologia Experimental e Biomedicina” (CNC, Coimbra, Portugal)) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/nature09965 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Shank3 mutant mice display autistic-like behaviours and striatal dysfunction | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Peça, João, Cátia Feliciano, Jonathan T. Ting, Wenting Wang, Michael F. Wells, Talaignair N. Venkatraman, Christopher D. Lascola, Zhanyan Fu, and Guoping Feng. “Shank3 Mutant Mice Display Autistic-Like Behaviours and Striatal Dysfunction.” Nature 472, no. 7344 (April 28, 2011): 437–442. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
dc.contributor.mitauthor | Fu, Zhanyan | en_US |
dc.contributor.mitauthor | Feng, Guoping | en_US |
dc.relation.journal | Nature | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Peça, João; Feliciano, Cátia; Ting, Jonathan T.; Wang, Wenting; Wells, Michael F.; Venkatraman, Talaignair N.; Lascola, Christopher D.; Fu, Zhanyan; Feng, Guoping | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-8021-277X | |
dc.identifier.orcid | https://orcid.org/0000-0001-9473-2402 | |
mit.license | OPEN_ACCESS_POLICY | en_US |
mit.metadata.status | Complete | |