dc.contributor.author | Allsop, Stephen Azariah | |
dc.contributor.author | Vander Weele, Caitlin Miya | |
dc.contributor.author | Wichmann, Romy | |
dc.contributor.author | Tye, Kay | |
dc.date.accessioned | 2014-09-09T14:15:30Z | |
dc.date.available | 2014-09-09T14:15:30Z | |
dc.date.issued | 2014-07 | |
dc.date.submitted | 2014-02 | |
dc.identifier.issn | 1662-5153 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/89222 | |
dc.description.abstract | Many psychiatric illnesses are characterized by deficits in the social domain. For example, there is a high rate of co-morbidity between autism spectrum disorders and anxiety disorders. However, the common neural circuit mechanisms by which social deficits and other psychiatric disease states, such as anxiety, are co-expressed remains unclear. Here, we review optogenetic investigations of neural circuits in animal models of anxiety-related behaviors and social behaviors and discuss the important role of the amygdala in mediating aspects of these behaviors. In particular, we focus on recent evidence that projections from the basolateral amygdala (BLA) to the ventral hippocampus (vHPC) modulate anxiety-related behaviors and also alter social interaction. Understanding how this circuit influences both social behavior and anxiety may provide a mechanistic explanation for the pathogenesis of social anxiety disorder, as well as the prevalence of patients co-diagnosed with autism spectrum disorders and anxiety disorders. Furthermore, elucidating how circuits that modulate social behavior also mediate other complex emotional states will lead to a better understanding of the underlying mechanisms by which social deficits are expressed in psychiatric disease. | en_US |
dc.description.sponsorship | Picower Institute for Learning and Memory (PIIFFunds) | en_US |
dc.description.sponsorship | JPB Foundation | en_US |
dc.description.sponsorship | Whitehall Foundation | en_US |
dc.description.sponsorship | Esther A. & Joseph Klingenstein Fund, Inc. | en_US |
dc.description.sponsorship | Whitehead Institute for Biomedical Research (Whitehead Career Development Professorship) | en_US |
dc.description.sponsorship | Alfred P. Sloan Foundation | en_US |
dc.description.sponsorship | National Alliance for Research on Schizophrenia and Depression (U.S.) (NARSAD Young Investigator Award) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (NIH New Innovator Award (DP2-DK-102256-01)) | en_US |
dc.description.sponsorship | National Institute of Mental Health (U.S.) (NIMH (R01-MH102441-01)) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences (Jeffrey (76) and Nancy Halis Fellowship) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Dept. of Brain and Cognitive Sciences (Henry E. Singleton (1940) Fund) | en_US |
dc.description.sponsorship | National Institute of General Medical Sciences (U.S.) (NIGMS T32 (GM007484)) | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Simons Center for the Social Brain | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology (NOW Rubicon Program) | en_US |
dc.language.iso | en_US | |
dc.publisher | Frontiers Research Foundation | en_US |
dc.relation.isversionof | http://dx.doi.org/10.3389/fnbeh.2014.00241 | en_US |
dc.rights | Creative Commons Attribution | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Frontiers Research Foundation | en_US |
dc.title | Optogenetic insights on the relationship between anxiety-related behaviors and social deficits | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Allsop, Stephen A., Caitlin M. Vander Weele, Romy Wichmann, and Kay M. Tye. “Optogenetic Insights on the Relationship Between Anxiety-Related Behaviors and Social Deficits.” Front. Behav. Neurosci. 8 (July 16, 2014). | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | Picower Institute for Learning and Memory | en_US |
dc.contributor.mitauthor | Allsop, Stephen Azariah | en_US |
dc.contributor.mitauthor | Vander Weele, Caitlin Miya | en_US |
dc.contributor.mitauthor | Wichmann, Romy | en_US |
dc.contributor.mitauthor | Tye, Kay | en_US |
dc.relation.journal | Frontiers in Behavioral Neuroscience | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Allsop, Stephen A.; Vander Weele, Caitlin M.; Wichmann, Romy; Tye, Kay M. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-8269-2615 | |
dc.identifier.orcid | https://orcid.org/0000-0002-0438-3163 | |
dc.identifier.orcid | https://orcid.org/0000-0002-4506-8813 | |
mit.license | PUBLISHER_CC | en_US |
mit.metadata.status | Complete | |