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Microneedles for Drug Delivery via the Gastrointestinal Tract

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dc.contributor.author Schroeder, Avi
dc.contributor.author Maa, Ruby
dc.contributor.author Lauwers, Gregory Y.
dc.contributor.author Polat, Baris E.
dc.contributor.author Blankschtein, Daniel
dc.contributor.author Langer, Robert
dc.contributor.author Traverso, Gio
dc.contributor.author Schoellhammer, Carl Magnus
dc.contributor.author Anderson, Daniel Griffith
dc.date.accessioned 2014-10-01T15:55:35Z
dc.date.available 2014-10-01T15:55:35Z
dc.date.issued 2014-09
dc.date.submitted 2014-08
dc.identifier.issn 00223549
dc.identifier.issn 1520-6017
dc.identifier.uri http://hdl.handle.net/1721.1/90508
dc.description.abstract Both patients and physicians prefer the oral route of drug delivery. The gastrointestinal (GI) tract, though, limits the bioavailability of certain therapeutics because of its protease and bacteria-rich environment as well as general pH variability from pH 1 to 7. These extreme environments make oral delivery particularly challenging for the biologic class of therapeutics. Here, we demonstrate proof-of-concept experiments in swine that microneedle-based delivery has the capacity for improved bioavailability of a biologically active macromolecule. Moreover, we show that microneedle-containing devices can be passed and excreted from the GI tract safely. These findings strongly support the success of implementation of microneedle technology for use in the GI tract. en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Grant EB000244) en_US
dc.description.sponsorship National Institutes of Health (U.S.) (Grant T32DK7191-38-S1) en_US
dc.language.iso en_US
dc.publisher Wiley Blackwell en_US
dc.relation.isversionof http://dx.doi.org/10.1002/jps.24182 en_US
dc.rights Creative Commons Attribution-Noncommercial-Share Alike en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/ en_US
dc.source Traverso en_US
dc.title Microneedles for Drug Delivery via the Gastrointestinal Tract en_US
dc.type Article en_US
dc.identifier.citation Traverso, Giovanni, Carl M. Schoellhammer, Avi Schroeder, Ruby Maa, Gregory Y. Lauwers, Baris E. Polat, Daniel G. Anderson, Daniel Blankschtein, and Robert Langer. “Microneedles for Drug Delivery via the Gastrointestinal Tract.” J. Pharm. Sci. (September 2014). en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Chemical Engineering en_US
dc.contributor.department David H. Koch Institute for Integrative Cancer Research at MIT en_US
dc.contributor.department Institute for Medical Engineering and Science en_US
dc.contributor.department Harvard University--MIT Division of Health Sciences and Technology en_US
dc.contributor.mitauthor Traverso, Gio en_US
dc.contributor.mitauthor Schoellhammer, Carl Magnus en_US
dc.contributor.mitauthor Schroeder, Avi en_US
dc.contributor.mitauthor Maa, Ruby en_US
dc.contributor.mitauthor Polat, Baris E. en_US
dc.contributor.mitauthor Anderson, Daniel Griffith en_US
dc.contributor.mitauthor Blankschtein, Daniel en_US
dc.contributor.mitauthor Langer, Robert en_US
dc.relation.journal Journal of Pharmaceutical Sciences en_US
dc.identifier.mitlicense OPEN_ACCESS_POLICY en_US
dc.eprint.version Author's final manuscript en_US
dc.type.uri http://purl.org/eprint/type/JournalArticle en_US
eprint.status http://purl.org/eprint/status/PeerReviewed en_US
dspace.orderedauthors Traverso, Giovanni; Schoellhammer, Carl M.; Schroeder, Avi; Maa, Ruby; Lauwers, Gregory Y.; Polat, Baris E.; Anderson, Daniel G.; Blankschtein, Daniel; Langer, Robert en_US
dc.identifier.orcid https://orcid.org/0000-0001-6694-6761
dc.identifier.orcid https://orcid.org/0000-0001-5629-4798
dc.identifier.orcid https://orcid.org/0000-0002-4260-2785
dc.identifier.orcid https://orcid.org/0000-0002-7836-415X
dc.identifier.orcid https://orcid.org/0000-0003-4255-0492


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