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dc.contributor.authorSinha, Pawan
dc.contributor.authorKjelgaard, Margaret McCaughin
dc.contributor.authorGandhi, Tapan Kumar
dc.contributor.authorTsourides, Kleovoulos
dc.contributor.authorCardinaux, Annie
dc.contributor.authorPantazis, Dimitrios
dc.contributor.authorDiamond, Sidney
dc.contributor.authorHeld, Richard M.
dc.date.accessioned2014-10-09T15:40:39Z
dc.date.available2014-10-09T15:40:39Z
dc.date.issued2014-10
dc.date.submitted2014-09
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/90824
dc.description.abstractA rich collection of empirical findings accumulated over the past three decades attests to the diversity of traits that constitute the autism phenotypes. It is unclear whether subsets of these traits share any underlying causality. This lack of a cohesive conceptualization of the disorder has complicated the search for broadly effective therapies, diagnostic markers, and neural/genetic correlates. In this paper, we describe how theoretical considerations and a review of empirical data lead to the hypothesis that some salient aspects of the autism phenotype may be manifestations of an underlying impairment in predictive abilities. With compromised prediction skills, an individual with autism inhabits a seemingly “magical” world wherein events occur unexpectedly and without cause. Immersion in such a capricious environment can prove overwhelming and compromise one’s ability to effectively interact with it. If validated, this hypothesis has the potential of providing unifying insights into multiple aspects of autism, with attendant benefits for improving diagnosis and therapy.en_US
dc.description.sponsorshipMassachusetts Institute of Technology. Simons Center for the Social Brainen_US
dc.description.sponsorshipSimons Foundationen_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1416797111en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleAutism as a disorder of predictionen_US
dc.typeArticleen_US
dc.identifier.citationSinha, P., M. M. Kjelgaard, T. K. Gandhi, K. Tsourides, A. L. Cardinaux, D. Pantazis, S. P. Diamond, and R. M. Held. “Autism as a Disorder of Prediction.” Proceedings of the National Academy of Sciences (October 6, 2014).en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorSinha, Pawanen_US
dc.contributor.mitauthorKjelgaard, Margaret McCaughinen_US
dc.contributor.mitauthorGandhi, Tapan Kumaren_US
dc.contributor.mitauthorTsourides, Kleovoulosen_US
dc.contributor.mitauthorCardinaux, Annieen_US
dc.contributor.mitauthorPantazis, Dimitriosen_US
dc.contributor.mitauthorDiamond, Sidneyen_US
dc.contributor.mitauthorHeld, Richard M.en_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSinha, P.; Kjelgaard, M. M.; Gandhi, T. K.; Tsourides, K.; Cardinaux, A. L.; Pantazis, D.; Diamond, S. P.; Held, R. M.en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5615-1823
dc.identifier.orcidhttps://orcid.org/0000-0002-8259-7079
dc.identifier.orcidhttps://orcid.org/0000-0002-8621-8646
dc.identifier.orcidhttps://orcid.org/0000-0002-5886-9003
mit.licensePUBLISHER_POLICYen_US


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