dc.contributor.author | Burguiere, Eric | |
dc.contributor.author | Monteiro, Patricia | |
dc.contributor.author | Feng, Guoping | |
dc.contributor.author | Graybiel, Ann M. | |
dc.date.accessioned | 2014-10-21T14:04:15Z | |
dc.date.available | 2014-10-21T14:04:15Z | |
dc.date.issued | 2013-06 | |
dc.date.submitted | 2012-11 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.issn | 1095-9203 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/91012 | |
dc.description.abstract | Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric disorders, including those characterized by the presence of repetitive behaviors. We developed an optogenetic approach to block repetitive, compulsive behavior in a mouse model in which deletion of the synaptic scaffolding gene, Sapap3, results in excessive grooming. With a delay-conditioning task, we identified in the mutants a selective deficit in behavioral response inhibition and found this to be associated with defective down-regulation of striatal projection neuron activity. Focused optogenetic stimulation of the lateral orbitofrontal cortex and its terminals in the striatum restored the behavioral response inhibition, restored the defective down-regulation, and compensated for impaired fast-spiking neuron striatal microcircuits. These findings raise promising potential for the design of targeted therapy for disorders involving excessive repetitive behavior. | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Simons Center for the Social Brain | en_US |
dc.description.sponsorship | Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (NIH R37 HD028341) | en_US |
dc.description.sponsorship | United States. Defense Advanced Research Projects Agency (W911NF1010059) | en_US |
dc.description.sponsorship | National Institute of Mental Health (U.S.) (NIH R01 MH081201) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1126/science.1232380 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Burguiere, E., P. Monteiro, G. Feng, and A. M. Graybiel. “Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors.” Science 340, no. 6137 (June 6, 2013): 1243–1246. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
dc.contributor.mitauthor | Burguiere, Eric | en_US |
dc.contributor.mitauthor | Monteiro, Patricia | en_US |
dc.contributor.mitauthor | Feng, Guoping | en_US |
dc.contributor.mitauthor | Graybiel, Ann M. | en_US |
dc.relation.journal | Science | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Burguiere, E.; Monteiro, P.; Feng, G.; Graybiel, A. M. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-3288-4560 | |
dc.identifier.orcid | https://orcid.org/0000-0002-8021-277X | |
dc.identifier.orcid | https://orcid.org/0000-0002-4326-7720 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |