GABA Neurons of the VTA Drive Conditioned Place Aversion
Author(s)Tan, Kelly R.; Turiault, Marc; Mirzabekov, Julie J.; Doehner, Jana; Deisseroth, Karl; Tye, Kay; Yvon, Cedric; Labouebe, Gwenael; Luscher, Christian; ... Show more Show less
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Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA[subscript A] receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
DepartmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Tan, Kelly R., Cedric Yvon, Marc Turiault, Julie J. Mirzabekov, Jana Doehner, Gwenael Labouebe, Karl Deisseroth, Kay M. Tye, and Christian Luscher. “GABA Neurons of the VTA Drive Conditioned Place Aversion.” Neuron 73, no. 6 (March 2012): 1173–1183. © 2012 Elsevier Inc.
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