MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans
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The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation in the unc-71/adm-1 gene, which rescued the AVM neuron migration defect in mig-13 mutants. Genetic analyses revealed that UNC-71 at least partly acts downstream of MIG-13 and has an inhibitory effect on the anterior cell migration. The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
Date issued
2012-01Department
Massachusetts Institute of Technology. Department of BiologyJournal
FEBS Letters
Publisher
Elsevier
Citation
Masuda, Hitomi, Kuniaki Nakamura, Nozomu Takata, Bunsho Itoh, Takashi Hirose, Hiroki Moribe, Eisuke Mekada, and Masato Okada. “MIG-13 Controls Anteroposterior Cell Migration by Interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis Elegans.” FEBS Letters 586, no. 6 (March 2012): 740–746. © 2012 Federation of European Biochemical Societies
Version: Final published version
ISSN
00145793
1873-3468